Li Zhaoyang, Wang Jing, Han Xu, Yuan Jing, Guo Huan, Zhang Xiaomin, Zheng Dan, Tang Yuhan, Yang Handong, He Meian
1Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Rd, Wuhan, 430030 Hubei China.
2Dongfeng Central Hospital, Dongfeng Motor Corporation and Hubei University of Medicine, Shiyan, Hubei China.
Diabetol Metab Syndr. 2018 Apr 10;10:29. doi: 10.1186/s13098-018-0333-6. eCollection 2018.
Most of prior studies to demonstrate the association between mean platelet volume (MPV) and type 2 diabetes mellitus (T2DM) risk were cross-sectional design with inconsistent results. In the present prospective cohort study, we aimed to explore the relationship between MPV and incident T2DM risk among a middle-aged and older Chinese population.
This prospective study included 14,009 individuals derived from the Dongfeng-Tongji cohort which was launched in 2008. A total of 997 incident T2DM patients were diagnosed during the mean 4.51 years of follow-up period. MPV levels were divided into quartiles. The adjusted hazard ratios (HRs) and 95% confidence intervals (95% CIs) of incident T2DM was estimated by Cox proportional hazard models.
Compared with study participants with MPV < 7.49 fL, the HRs of T2DM incidence were 1.39 (95% CI 1.11-1.75), 1.14 (0.90-1.44), and 1.39 (95% CI 1.07-1.81) in study participants with 7.49 ≤ MPV < 8.43 fL, 8.43 fL ≤ MPV < 9.69 fL and MPV ≥ 9.69 fL, respectively. This positive association was more pronounced after exclusion of the newly diagnosed incident cases during the first 2 years follow-up. Further adjustment for baseline fasting blood glucose level (FBG) did not materially alter the positive association. The positive association was particularly evident among females, non-current smokers and study participants with FBG level less than 5.6 mmol/L at baseline.
Higher levels of MPV were independently associated with increased incident risk of T2DM in a middle-aged and older Chinese population.
大多数先前关于平均血小板体积（MPV）与2型糖尿病（T2DM）风险之间关联的研究采用横断面设计，结果不一致。在本前瞻性队列研究中，我们旨在探讨中国中老年人群中MPV与T2DM发病风险之间的关系。
这项前瞻性研究纳入了2008年启动的东风-同济队列中的14009名个体。在平均4.51年的随访期内，共诊断出997例新发T2DM患者。MPV水平分为四分位数。采用Cox比例风险模型估计T2DM发病的校正风险比（HR）和95%置信区间（95%CI）。
与MPV＜7.49 fL的研究参与者相比，MPV在7.49≤MPV＜8.43 fL、8.43 fL≤MPV＜9.69 fL和MPV≥9.69 fL的研究参与者中，T2DM发病的HR分别为1.39（95%CI 1.11-1.75）、1.14（0.90-1.44）和1.39（95%CI 1.07-1.81）。在排除随访前2年新诊断的病例后，这种正相关更为明显。进一步调整基线空腹血糖水平（FBG）并未实质性改变这种正相关。这种正相关在女性、非当前吸烟者以及基线FBG水平低于5.6 mmol/L的研究参与者中尤为明显。
在中国中老年人群中，较高的MPV水平与T2DM发病风险增加独立相关。
