McFadyen James D, Kaplan Zane S
Australian Centre for Blood Diseases, Monash University, Melbourne, Australia.
Australian Centre for Blood Diseases, Monash University, Melbourne, Australia.
Transfus Med Rev. 2015 Apr;29(2):110-9. doi: 10.1016/j.tmrv.2014.11.006. Epub 2015 Jan 12.
Although the role of platelets as central mediators of hemostasis and thrombosis has been the primary focus of research into platelet biology for more than a century, over the last decade, nonhemostatic functions of platelets have been increasingly defined. As such, a large body of experimental evidence now exists, which places the platelet as a key player in mediating a diverse range of immune, inflammatory, and malignant disease processes. This review outlines the central mechanisms that underpin the nonhemostatic role of platelets and provides a summary of evidence demonstrating a role for platelets in mediating selected inflammatory, immune, and malignant disease processes.
尽管一个多世纪以来，血小板作为止血和血栓形成的核心介质的作用一直是血小板生物学研究的主要焦点，但在过去十年中，血小板的非止血功能已得到越来越多的明确。因此，现在有大量的实验证据表明，血小板是介导多种免疫、炎症和恶性疾病过程的关键因素。本综述概述了血小板非止血作用的核心机制，并总结了证明血小板在介导特定炎症、免疫和恶性疾病过程中发挥作用的证据。
