First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Dis Markers. 2018 Jan 30;2018:8403937. doi: 10.1155/2018/8403937. eCollection 2018.
Dengue virus (DENV) is transmitted by mosquito and has been circulating in Guangdong, China, for over 30 years. Dengue infection causes mild to severe disease symptoms in human. Cytokine profiles were suggested to be crucial especially during the acute stage in the dengue infection.
To determine the cytokine profiles at the acute stage in patients with primary or secondary dengue infection in Guangzhou city in the 2014 outbreak.
We investigated 23 inflammatory cytokines in serum collected from dengue-infected patients and analyzed their correlations with their clinical indexes.
The concentrations of CXCL9, IP-10, CXCL11, IL-8, IL-10, and CCL2 in serum were significantly higher in the groups of DENV-infected patients during the first two weeks than those of control group while CCL17 and CXCL5 showed lower expression level in the patients. Among these cytokines, CXCL9, CCL17, and CXCL5 showed statistical difference between the groups of primary and secondary infections. The platelet count and lactate dehydrogenase were correlated with the level of CCL17 and MIP-1/CXCL5, respectively, in the group of secondary infection.
We determined the cytokine profiles in serum of the patients during the 2014 dengue outbreak. The expression of specific cytokines was associated with the secondary infection.
登革热病毒（DENV）通过蚊子传播，在中国广东已经流行了 30 多年。登革热感染会导致人类出现轻度至重度疾病症状。细胞因子谱被认为在登革热感染的急性期尤其重要。
在 2014 年广州登革热疫情中，确定初次或再次感染登革热患者在急性期的细胞因子谱。
我们调查了血清中 23 种炎症细胞因子，分析它们与临床指标的相关性。
在感染登革热的患者中，在感染的前两周，血清中 CXCL9、IP-10、CXCL11、IL-8、IL-10 和 CCL2 的浓度明显高于对照组，而 CCL17 和 CXCL5 的表达水平较低。在这些细胞因子中，初次和再次感染组之间 CXCL9、CCL17 和 CXCL5 的差异具有统计学意义。血小板计数和乳酸脱氢酶与继发感染组中 CCL17 和 MIP-1/CXCL5 的水平分别相关。
我们确定了 2014 年登革热疫情期间患者血清中的细胞因子谱。特定细胞因子的表达与继发感染有关。
