Department of Radiation Oncology, Fortis Memorial Research Institute, 122002, Gurgaon, Haryana, India.
Department of Radiology, Fortis Memorial Research Institute, Gurgaon, Haryana, India.
Strahlenther Onkol. 2018 Aug;194(8):711-718. doi: 10.1007/s00066-018-1299-x. Epub 2018 Apr 12.
Radiotherapy for breast cancer has been associated with various side effects including cardiac sequelae. Our study aimed to define the spatial arc of spread of coronary vessels in a radian angle.
We analysed the records of 51 CT coronary angiographies done in our hospital from January 2016 to July 2016. Left anterior descending (LAD) and right coronary (RC) were contoured for each patient. In each axial section, the radial spread of each artery was noted. A 5 mm brush tool was used to join the start and stop angles for making the summated "coronary strips".
Start and end angle of LAD with 95% confidence interval (CI) (in clockwise direction) were 23.9 ± 4° and 79.0 ± 6.6°, respectively. Mean LAD arc length ± SD (standard deviation) noted was 55.1° ± 7.7° (95% CI). For RC the smallest start angle and the largest end angle in all patients was 297.6° and 322.6°, respectively. RC start angle, end angle and arc length for 95% confidence interval were 322.2 ± 6.1°, 292.4 ± 11.6° and 29.8 ± 13.1°, respectively.
Our study provides a measure of the radial spread of the coronary arteries, especially from the perspective of breast radiotherapy. We have proposed a new organ at risk (OAR) of coronary strip. This should provide an easy and cost-effective way to delineate the coronary vasculature in breast cancer patients undergoing radiotherapy.
乳腺癌放射治疗可引起多种副作用，包括心脏后遗症。本研究旨在定义冠状动脉在辐射角中的空间扩展弧。
我们分析了 2016 年 1 月至 7 月期间在我院进行的 51 例 CT 冠状动脉造影的记录。为每位患者勾画左前降支（LAD）和右冠状动脉（RC）。在每个轴向切片中，记录每条动脉的辐射扩散角度。使用 5mm 的画笔工具连接起始和停止角度，以制作总和“冠状动脉带”。
LAD 的起始和结束角度（以顺时针方向）的 95%置信区间（CI）分别为 23.9°±4°和 79.0°±6.6°。注意到的平均 LAD 弧长为 55.1°±7.7°（95%CI）。对于 RC，所有患者中最小的起始角度和最大的结束角度分别为 297.6°和 322.6°。RC 的起始角度、结束角度和 95%CI 的弧长分别为 322.2°±6.1°、292.4°±11.6°和 29.8°±13.1°。
我们的研究提供了冠状动脉辐射扩散的测量方法，特别是从乳腺癌放射治疗的角度来看。我们提出了一种新的冠状动脉带危险器官（OAR）。这应该为乳腺癌放疗患者的冠状动脉血管描边提供一种简单且具有成本效益的方法。
