合成大鼠心房利钠多肽对正常血压大鼠的中枢致渴作用

Central dipsogenic effect of synthetic rat atrial natriuretic polypeptide in normotensive rats.

作者信息

Squadrito F, Calapai G, Autolitano A, Frisina N, Santoro G, Buemi M, Squadrito G, Caputi A P

机构信息

Institute of Pharmacology, Medical School, University of Messina, Italy.

出版信息

Jpn J Pharmacol. 1987 Dec;45(4):567-9. doi: 10.1254/jjp.45.567.

DOI:10.1254/jjp.45.567

PMID:2965271

Abstract

The effect of intracerebroventricular (i.c.v.) injection of synthetic rat atrial natriuretic polypeptide (alpha-rANP) on drinking behavior was studied in normotensive rats, alpha-rANP (0.2, 0.4 or 0.8 micrograms in 5 microliter) caused a dose-dependent dipsogenic effect which was abated by i.c.v. pretreatment with saralasine (9 micrograms in 5 microliter). These results suggest that alpha-rANP possesses dipsogenic effects in water repleted rats and that brain angiotensin is involved. In addition, our data indicate that, at least as far as the effect of cerebral ANP is concerned, there are some differences between alpha-rANP and human atrial natriuretic polypeptide.

摘要

在正常血压大鼠中研究了脑室内（i.c.v.）注射合成大鼠心房利钠多肽（α-rANP）对饮水行为的影响。α-rANP（5微升中含0.2、0.4或0.8微克）引起剂量依赖性的致渴效应，而预先脑室内注射肌丙抗增压素（5微升中含9微克）可减轻该效应。这些结果表明，α-rANP在水充足的大鼠中具有致渴作用，且脑内血管紧张素参与其中。此外，我们的数据表明，至少就脑内ANP的作用而言，α-rANP与人心房利钠多肽之间存在一些差异。