Tichá V, Jansa P, Tichý M
Department of Pathology, School of Medicine, Palacký University, Olomouc, Czechoslovakia.
Neoplasma. 1988;35(1):91-102.
The histochemical properties of mucus in 48 diffuse type gastric carcinomas and in 46 intestinal type gastric cancers were investigated. In the diffuse type there was a prevalence of intracellular secretion of mucopolysaccharides with a significantly larger portion of sulfated mucopolysaccharides. Acid mucopolysaccharides occurred in the tumor cells only along with neutral ones. In the intestinal type of this cancer, in turn, extracellular secretion prevailed, along with the occurrence of purely acid mucopolysaccharides and a smaller portion of sulfated ones. The secretion of pure neutral mucopolysaccharides in both types of gastric cancer was very low. In the marginal areas of intestinal type carcinomas, incomplete intestinal type IIb metaplasia was frequently found.
对48例弥漫型胃癌和46例肠型胃癌的黏液组织化学特性进行了研究。在弥漫型中，黏多糖的细胞内分泌占优势，硫酸化黏多糖的比例明显更大。酸性黏多糖仅与中性黏多糖一起出现在肿瘤细胞中。而在这种癌症的肠型中，细胞外分泌占优势，同时存在纯酸性黏多糖和较小比例的硫酸化黏多糖。两种类型的胃癌中纯中性黏多糖的分泌都非常低。在肠型癌的边缘区域，经常发现不完全的肠型IIb化生。
