Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga, Guimarães, Portugal; Cardiology Department, Hospital of Braga, Braga, Portugal.
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga, Guimarães, Portugal.
J Mol Cell Cardiol. 2018 Jun;119:1-9. doi: 10.1016/j.yjmcc.2018.04.005. Epub 2018 Apr 10.
Cardiac function is under the control of the autonomic nervous system, composed by the parasympathetic and sympathetic divisions, which are finely tuned at different hierarchical levels. While a complex regulation occurs in the central nervous system involving the insular cortex, the amygdala and the hypothalamus, a local cardiac regulation also takes place within the heart, driven by an intracardiac nervous system. This complex system consists of a network of ganglionic plexuses and interconnecting ganglions and axons. Each ganglionic plexus contains numerous intracardiac ganglia that operate as local integration centres, modulating the intricate autonomic interactions between the extrinsic and intracardiac nervous systems. Herein, we summarize the current understanding on the intracardiac nervous system, and acknowledge its role in the pathophysiology of cardiovascular diseases.
心脏功能受自主神经系统控制，自主神经系统由副交感神经和交感神经组成，它们在不同的层次上精细地调节。虽然在中枢神经系统中涉及脑岛皮质、杏仁核和下丘脑等部位会发生复杂的调节，但心脏内部也会发生局部的心脏调节，由心脏内神经系统驱动。这个复杂的系统由神经丛网络和相互连接的神经节和轴突组成。每个神经丛包含许多作为局部整合中心的心脏内神经节，调节外在和心脏内神经系统之间错综复杂的自主相互作用。本文总结了目前对心脏内神经系统的理解，并承认其在心血管疾病病理生理学中的作用。
