Department of Abdominal Oncology, Zhejiang Cancer Hospital, Hangzhou, China.
Department of Preventative Medicine, Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, Medical School of Ningbo University, Ningbo, China.
Gene. 2018 Jul 1;662:103-109. doi: 10.1016/j.gene.2018.04.023. Epub 2018 Apr 10.
Accumulating evidence suggests that the aberrant expression of long non-coding RNAs is closely related to the carcinogenesis and progression of gastric cancer (GC), which is a type of prevalent tumor with a high incidence and mortality rate. However, it is still a challenge to find reliable biomarkers and to understand their molecular mechanisms in GC. In this study, we first confirmed that LINC00941was up-regulated in GC tumor tissues compared with adjacent normal tissues by RT-PCR, and found that the expression level of LINC00941 was correlated with invasion depth, lymphatic metastasis, and the TNM stage of patients with GC. Furthermore, by performing enrichment analysis based on the co-expression network and regulatory network, we found that LINC00941 was associated with cancer related biological processes such as cell cycle, cell communication, cell migration, cell division, as well as processes associated with the immune system. Our results suggested that LINC00941 may be a potential novel biomarker for therapeutic or diagnostic of GC.
越来越多的证据表明，长非编码 RNA 的异常表达与胃癌（GC）的发生和发展密切相关，GC 是一种发病率和死亡率都很高的常见肿瘤。然而，寻找可靠的生物标志物并了解其在 GC 中的分子机制仍然是一个挑战。在这项研究中，我们首先通过 RT-PCR 证实 LINC00941 在 GC 肿瘤组织中的表达水平高于相邻正常组织，并发现 LINC00941 的表达水平与 GC 患者的浸润深度、淋巴转移和 TNM 分期相关。此外，通过基于共表达网络和调控网络的富集分析，我们发现 LINC00941 与细胞周期、细胞通讯、细胞迁移、细胞分裂等与癌症相关的生物学过程以及与免疫系统相关的过程有关。我们的研究结果表明，LINC00941 可能是 GC 治疗或诊断的潜在新型生物标志物。
