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本文引用的文献

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Birth Outcomes in Children Fathered by Men Treated with Anti-TNF-α Agents Before Conception.受孕前接受抗TNF-α药物治疗的男性所育子女的出生结局
Am J Gastroenterol. 2016 Nov;111(11):1608-1613. doi: 10.1038/ajg.2016.405. Epub 2016 Sep 13.
2
Reassuring results on birth outcomes in children fathered by men treated with azathioprine/6-mercaptopurine within 3 months before conception: a nationwide cohort study.在受孕前 3 个月内接受硫唑嘌呤/巯基嘌呤治疗的男性所生育的孩子的出生结局有令人安心的结果：一项全国性队列研究。
Gut. 2017 Oct;66(10):1761-1766. doi: 10.1136/gutjnl-2016-312123. Epub 2016 Jul 25.
3
Pregnancy and the Patient with Inflammatory Bowel Disease: Fertility, Treatment, Delivery, and Complications.妊娠与炎症性肠病患者：生育力、治疗、分娩及并发症
Gastroenterol Clin North Am. 2016 Jun;45(2):285-301. doi: 10.1016/j.gtc.2016.02.006.
4
Preconception Care Reduces Relapse of Inflammatory Bowel Disease During Pregnancy.孕前保健可降低炎症性肠病孕妇的复发率。
Clin Gastroenterol Hepatol. 2016 Sep;14(9):1285-1292.e1. doi: 10.1016/j.cgh.2016.03.018. Epub 2016 Mar 18.
5
Development of an internet-based cohort of patients with inflammatory bowel diseases (CCFA Partners): methodology and initial results.基于互联网的炎症性肠病患者队列的开发（CCFA 合作伙伴）：方法学和初步结果。
Inflamm Bowel Dis. 2012 Nov;18(11):2099-106. doi: 10.1002/ibd.22895. Epub 2012 Jan 27.
6
Sulphasalazine induced seminal abnormalities in ulcerative colitis: results of mesalazine substitution.柳氮磺胺吡啶诱发溃疡性结肠炎患者精液异常：美沙拉嗪替代治疗的结果
Gut. 1987 Aug;28(8):1008-12. doi: 10.1136/gut.28.8.1008.
7
Male infertility in inflammatory bowel disease.炎症性肠病中的男性不育
J Clin Gastroenterol. 1989 Aug;11(4):403-6. doi: 10.1097/00004836-198908000-00011.
8
Effects of mesalazine substitution on salicylazosulfapyridine-induced seminal abnormalities in men with ulcerative colitis.美沙拉嗪替代对溃疡性结肠炎男性患者柳氮磺胺吡啶诱导的精液异常的影响。
Scand J Gastroenterol. 1989 Sep;24(7):891-6. doi: 10.3109/00365528909089231.

父亲的疾病活动与炎症性肠病男性受孕困难有关。

Paternal Disease Activity Is Associated With Difficulty in Conception Among Men With Inflammatory Bowel Diseases.

机构信息

Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina.

出版信息

Clin Gastroenterol Hepatol. 2019 Jan;17(1):203-204. doi: 10.1016/j.cgh.2018.04.001. Epub 2018 Apr 11.

DOI:10.1016/j.cgh.2018.04.001
PMID:29653290
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6181789/
Abstract

The impact of inflammatory bowel disease (IBD) activity and treatment on fertility and pregnancy outcomes is important for men and women. In women, remission at conception determines better pregnancy outcomes, and most maternal IBD medication exposures are safe. In contrast, less is known about the impact of paternal disease activity and medication use on fertility and pregnancy outcomes in men with IBD..

摘要

炎症性肠病（IBD）活动和治疗对男性和女性的生育和妊娠结局有重要影响。对于女性来说，受孕时的缓解可决定更好的妊娠结局，且大多数母体 IBD 药物暴露是安全的。相比之下，对于患有 IBD 的男性，其疾病活动和药物使用对生育和妊娠结局的影响知之甚少。