Narendranathan M, Sandler R S, Suchindran C M, Savitz D A
Department of Medicine, University of North Carolina, Chapel Hill 27599-7080.
J Clin Gastroenterol. 1989 Aug;11(4):403-6. doi: 10.1097/00004836-198908000-00011.
We examined fertility in men with inflammatory bowel disease (IBD) to determine whether the reported deficit in pregnancies in their spouses was due to reduced reproductive capacity. The cases were 106 men with Crohn's disease and 62 with ulcerative colitis drawn from the rosters of North Carolina chapters of the National Foundation for Ileitis and Colitis. The 140 normal controls were neighbors identified by the cases. There were 186 pregnancies among the spouses of men with Crohn's disease, 110 among the ulcerative colitis group, and 300 among the controls. The mean number of pregnancies among the Crohn's disease patients (1.75 +/- 0.12) was significantly lower than the number for controls (2.14 +/- 0.11), p less than 0.02. The reduction in the mean number of pregnancies among patients with ulcerative colitis (1.77 +/- 0.18) was not significantly different from controls (p less than 0.07). Analysis of waiting time to conception showed that fecundability (the probability of pregnancy in a menstrual cycle) was not different in spouses of IBD patients and controls. We conclude that the overall reproductive capacity of men with IBD is not markedly diminished.
我们研究了炎症性肠病（IBD）男性患者的生育能力，以确定其配偶妊娠率降低是否归因于生殖能力下降。病例包括从北卡罗来纳州回肠炎和结肠炎国家基金会分会名册中选取的106例克罗恩病男性患者和62例溃疡性结肠炎男性患者。140名正常对照者是由病例确定的邻居。克罗恩病男性患者的配偶中有186次妊娠，溃疡性结肠炎组中有110次妊娠，对照组中有300次妊娠。克罗恩病患者的平均妊娠次数（1.75±0.12）显著低于对照组（2.14±0.11），p<0.02。溃疡性结肠炎患者平均妊娠次数的减少（1.77±0.18）与对照组无显著差异（p<0.07）。对受孕等待时间的分析表明，IBD患者配偶和对照组的受孕能力（月经周期内怀孕的概率）没有差异。我们得出结论，IBD男性患者的整体生殖能力没有明显下降。
