具有高光热转换效率的生物相容 Fe-TA 配位配合物用于癌细胞的消融。
Biocompatible Fe-TA coordination complex with high photothermal conversion efficiency for ablation of cancer cells.
机构信息
School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China; MOE Key Laboratory of Micro-Systems and Micro-Structures Manufacturing, Harbin Institute of Technology, Harbin 150080, China.
School of Life Science and Engineering, Harbin Institute of Technology, Harbin 150080, China.
出版信息
Colloids Surf B Biointerfaces. 2018 Jul 1;167:183-190. doi: 10.1016/j.colsurfb.2018.03.030. Epub 2018 Mar 22.
Near-infrared (NIR) light absorbing nanomaterials, which can convert light to heat energy, have great prospects in biomedical applications. In the current work, Fe-TA (Tannic Acid) coordination complex formed by simple mixing of tannic acid and FeCl solutions was explored as a novel photothermal agent. Due to the strong absorbance in the near-infrared region induced by the coordination effect between TA molecule and Fe ion, the as-prepared Fe-TA complex exhibited excellent photothermal performance with high photothermal conversion efficiency of 77.3% and high photothermal stability. Upon the exposure to Fe-TA aqueous dispersions with a concentration of 0.125 mg/mL, the cell mortality of HeLa cells was more than 85% after being irradiated for 10 min under NIR light (808 nm, 6 W cm). Besides, the Fe-TA complex exhibited ultralow cytotoxicity since only biocompatible tannic acid and iron ions were used as raw materials. Therefore, the merits of simple and convenient fabrication method, high photothermal conversion efficiency and excellent biocompatibility endow the high potential of Fe-TA complex as a photothermal agent for biomedical applications.
近红外（NIR）光吸收纳米材料可以将光转化为热能，在生物医学应用中具有广阔的前景。在目前的工作中，探索了由单宁酸和 FeCl 溶液简单混合形成的 Fe-TA（单宁酸）配合物作为一种新型光热剂。由于 TA 分子与 Fe 离子之间的配位作用引起的近红外区域的强吸收，所制备的 Fe-TA 配合物表现出优异的光热性能，具有 77.3%的高光热转换效率和高光热稳定性。在暴露于浓度为 0.125mg/mL 的 Fe-TA 水分散体后，在 NIR 光（808nm，6W/cm）下照射 10min 后，HeLa 细胞的细胞死亡率超过 85%。此外，由于仅使用了单宁酸和铁离子作为原料，因此 Fe-TA 配合物具有超低的细胞毒性。因此，制备方法简单方便、高光热转换效率和优异的生物相容性赋予了 Fe-TA 配合物作为光热剂在生物医学应用中的巨大潜力。
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