Jia Xintao, Dou Zixuan, Zhang Ying, Li Fanqin, Xing Bin, Hu Zheming, Li Xin, Liu Zhongyan, Yang Wenzhuo, Liu Zhidong
State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Pharmaceutics. 2023 Dec 6;15(12):2735. doi: 10.3390/pharmaceutics15122735.
Chronic wounds are a major health challenge that require new treatment strategies. Hydrogels are promising drug delivery systems for chronic wound healing because of their biocompatibility, hydration, and flexibility. However, conventional hydrogels cannot adapt to the dynamic and complex wound environment, which involves low pH, high levels of reactive oxygen species, and specific enzyme expression. Therefore, smart responsive hydrogels that can sense and respond to these stimuli are needed. Crucially, smart responsive hydrogels can modulate drug release and eliminate pathological factors by changing their properties or structures in response to internal or external stimuli, such as pH, enzymes, light, and electricity. These stimuli can also be used to trigger antibacterial responses, angiogenesis, and cell proliferation to enhance wound healing. In this review, we introduce the synthesis and principles of smart responsive hydrogels, describe their design and applications for chronic wound healing, and discuss their future development directions. We hope that this review will inspire the development of smart responsive hydrogels for chronic wound healing.
慢性伤口是一项重大的健康挑战，需要新的治疗策略。水凝胶因其生物相容性、保湿性和柔韧性，是用于慢性伤口愈合的很有前景的药物递送系统。然而，传统水凝胶无法适应动态且复杂的伤口环境，该环境包括低pH值、高活性氧水平和特定的酶表达。因此，需要能够感知并响应这些刺激的智能响应性水凝胶。至关重要的是，智能响应性水凝胶可以通过响应内部或外部刺激（如pH值、酶、光和电）来改变其性质或结构，从而调节药物释放并消除病理因素。这些刺激还可用于触发抗菌反应、血管生成和细胞增殖，以促进伤口愈合。在本综述中，我们介绍了智能响应性水凝胶的合成和原理，描述了它们在慢性伤口愈合中的设计和应用，并讨论了它们未来的发展方向。我们希望本综述能激发用于慢性伤口愈合的智能响应性水凝胶的开发。
