Department of Biology, Ecology and Earth Science (DiBEST), University of Calabria, Via P. Bucci 4/B, Rende, Cosenza, 87036, Italy.
Environ Toxicol Pharmacol. 2018 Jun;60:17-27. doi: 10.1016/j.etap.2018.04.007. Epub 2018 Apr 7.
Nonylphenol ethoxylates (NPEs) are well known endocrine disruptors. Widespread environmental contamination from NPEs is an issue of great concern. Despite amphibians are often exposed to such contaminants, very little attention has been dedicated to this vertebrate group. No information is available on the effects of NPEs onto the amphibian skin and only few reports have been conducted on fish. Here, histological and ultrastructural modifications of the skin have been evaluated in the Italian newt Lissotriton italicus. After a short-term exposure to two ecologically relevant concentrations of NP, severe pathological alterations, both dose and time-dependent, have been observed. The main effects were an increased mucous secretion, the dilation of the endomembrane, the wrinkling of the epidermal surface, the appearance of tubercles, the increased cellular turnover, continuous shedding processes. Some of the described skin alterations can easily interfere with physiological functions, such as osmoregulation and body protection, with detrimental consequences for the amphibian populations.
壬基酚聚氧乙烯醚（NPEs）是众所周知的内分泌干扰物。NPEs 广泛存在于环境中，对其造成的污染是一个令人关注的问题。尽管两栖动物经常暴露于此类污染物中，但对这一类脊椎动物的关注却很少。目前还没有关于 NPEs 对两栖动物皮肤影响的信息，仅有少数关于鱼类的报告。本研究中，评估了意大利蝾螈（Lissotriton italicus）皮肤的组织学和超微结构变化。在短期暴露于两种生态相关浓度的 NP 后，观察到严重的、剂量和时间依赖性的病理改变。主要影响包括粘液分泌增加、内质网扩张、表皮表面起皱、出现小结节、细胞更新增加和持续的脱落过程。一些描述的皮肤改变可能会轻易干扰生理功能，如渗透调节和身体保护，这对两栖动物种群有不利影响。
