乳杆菌和双歧杆菌作为肠道微生物群成员对慢性荨麻疹的保护作用。
The protective effect of Lactobacillus and Bifidobacterium as the gut microbiota members against chronic urticaria.
机构信息
Department of Microbiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Department of Immunology and Genetics, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
出版信息
Int Immunopharmacol. 2018 Jun;59:168-173. doi: 10.1016/j.intimp.2018.04.007. Epub 2018 Apr 11.
BACKGROUND
Chronic Urticaria is a common disorder which is defined by recurrent occurrence of wheals and sometimes angioedema. It has a notable influence on the patients' quality of life. Regulation of the immune system is one of the important roles of the gut microbiota. The effect of dysbiosis considering some members of gut microbiota in patients with chronic urticaria has been demonstrated in our previous study.
OBJECTIVE
Comparing the frequency and bacterial load of Lactobacillus, Bifidobacterium, and Bacteroides between patients with chronic urticaria and healthy controls.
METHODS
20 patients with chronic urticaria and 20 age and sex matched healthy individuals were included in the present study. Stool samples were analyzed for determining the frequency and bacterial load of Lactobacillus, Bifidobacterium, and Bacteroides genera.
RESULTS
There were no significant differences among the frequencies of detectable Lactobacillus, Bifidobacterium, or Bacteroides in stool samples of patients with chronic urticaria and healthy controls. The relative amounts of Lactobacillus and Bifidobacterium were significantly higher in fecal samples from controls compared to patients with chronic urticaria (P = 0.038 and 0.039, respectively).
CONCLUSION
It is the first study on the implication of Lactobacillus, Bifidobacterium, and Bacteroides genera as gut microbiota members in patients with chronic urticaria.
背景
慢性荨麻疹是一种常见疾病，其特征为反复发作的风团和（或）血管性水肿。它对患者的生活质量有显著影响。肠道微生物群对免疫系统的调节是其重要作用之一。我们之前的研究已经证实了慢性荨麻疹患者肠道微生物群某些成员失调的影响。
目的
比较慢性荨麻疹患者和健康对照者粪便中乳酸菌、双歧杆菌和拟杆菌的频率和细菌负荷。
方法
本研究纳入了 20 例慢性荨麻疹患者和 20 名年龄和性别匹配的健康个体。分析粪便样本以确定乳酸菌、双歧杆菌和拟杆菌属的频率和细菌负荷。
结果
慢性荨麻疹患者和健康对照者粪便中可检测到的乳酸菌、双歧杆菌或拟杆菌的频率无显著差异。与慢性荨麻疹患者相比，对照组粪便中乳酸菌和双歧杆菌的相对含量明显更高（分别为 P=0.038 和 0.039）。
结论
这是第一项关于乳酸菌、双歧杆菌和拟杆菌作为慢性荨麻疹患者肠道微生物群成员的意义的研究。
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