Child and Adolescent Psychiatry Department, University of Health Sciences, Ankara Child Health and Diseases Hematology Oncology Training and Research Hospital, Sehit Omer Halisdemir Caddesi, Kurtdereli Sokak, No: 10 06100, Diskapi/Ankara Turkey.
Child and Adolescent Psychiatry Department, University of Health Sciences, Ankara Child Health and Diseases Hematology Oncology Training and Research Hospital, Sehit Omer Halisdemir Caddesi, Kurtdereli Sokak, No: 10 06100, Diskapi/Ankara Turkey.
Psychiatry Res. 2018 Jun;264:231-235. doi: 10.1016/j.psychres.2018.04.006. Epub 2018 Apr 7.
Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent psychiatric disorders in children and the pathophysiology remains obscure. Some studies show that lipid imbalances are associated with ADHD etiology. We studied the association of serum total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglyceride (TG) levels in ADHD. We examined 88 children aged 8-12 years who were diagnosed with ADHD and 88 healthy children. The exclusion criteria were as follows: obesity, any psychotropic use in the last 3 months, presence of a chronic disease and/or malignancy, history of medically treated lipid metabolism disease in family members, intelligence quotient (IQ) < 70, and comorbidities, with the exception of oppositional defiant disorder. The sample was evaluated using a semi-structured clinical assessment interview and Conners' rating scales. Despite controlling for age, sex, and body mass index (BMI) variables, the total cholesterol and LDL levels were significantly higher in the ADHD group than the levels of healthy controls, whereas the TG and HDL cholesterol levels were similar among groups. Conners' rating scales, reflecting symptom severity, and total cholesterol, TG, HDL, and LDL levels of the ADHD group were not correlated. The study results support the difference in serum lipid and lipoprotein profiles of children with ADHD compared with healthy controls. This difference is thought to be related with changes in oxidant/antioxidant balance states in ADHD.
注意缺陷多动障碍（ADHD）是儿童中最常见的精神疾病之一，其病理生理学仍不清楚。一些研究表明，脂质失衡与 ADHD 的病因有关。我们研究了 ADHD 患者血清总胆固醇、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）和甘油三酯（TG）水平的相关性。我们检查了 88 名 8-12 岁被诊断为 ADHD 的儿童和 88 名健康儿童。排除标准如下：肥胖、过去 3 个月内使用任何精神药物、存在慢性疾病和/或恶性肿瘤、家族成员中有经医学治疗的脂质代谢疾病史、智商（IQ）<70 以及合并症，但对立违抗障碍除外。使用半结构化临床评估访谈和 Conners 评分量表对样本进行评估。尽管控制了年龄、性别和体重指数（BMI）变量，但 ADHD 组的总胆固醇和 LDL 水平明显高于健康对照组，而 TG 和 HDL 胆固醇水平在组间相似。反映症状严重程度的 Conners 评分量表以及 ADHD 组的总胆固醇、TG、HDL 和 LDL 水平均无相关性。研究结果支持 ADHD 儿童与健康对照组相比，血清脂质和脂蛋白谱存在差异。这种差异被认为与 ADHD 中氧化应激/抗氧化平衡状态的变化有关。
