Department of Child and Adolescent Psychiatry, Ankara City Hospital, Ankara, Turkey.
Department of Clinical Biochemistry, Erzincan University, Faculty of Medicine, Erzincan, Turkey.
Psychiatry Res. 2020 Dec;294:113546. doi: 10.1016/j.psychres.2020.113546. Epub 2020 Oct 29.
Attention deficit hyperactivity disorder (ADHD) is a childhood onset disorder with well-known findings that include impulsivity, hyperactivity, and inattention. This study aims to explore the relationship between the levels of ceruloplasmin, native thiol, total thiol, and disulfide and ADHD by comparing case and control groups. The study case group comprised 50 children aged 6-16 years who had been diagnosed with ADHD. The control group included 47 healthy children. Clinical interviews were conducted and the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version Turkish Adaptation and the Conners Parent Rating Scale were administered. Additionally, blood samples were taken and native thiol, total thiol, disulfide, and ceruloplasmin levels measured. In the ADHD group, the mean native thiol, total thiol, and disulfide levels were significantly lower than the control group. There was no significant difference between the ADHD and control groups in ceruloplasmin levels. Total thiol and native thiol levels were inversely correlated with scores on the Conners Inattention and Hyperactivity subscales; total thiol was negatively correlated with the ADHD index. Thiol-disulfide homeostasis was impaired in ADHD children and was related to symptom severity. Oxidative stress balance may play a role in ADHD.
注意缺陷多动障碍（ADHD）是一种儿童期起病的疾病，其特征为冲动、多动和注意力不集中等。本研究旨在通过比较病例组和对照组来探讨铜蓝蛋白、天然巯基、总巯基和二硫键水平与 ADHD 之间的关系。研究病例组包括 50 名年龄在 6-16 岁之间被诊断为 ADHD 的儿童。对照组包括 47 名健康儿童。进行了临床访谈，并使用儿童情感障碍和精神分裂症谱系障碍筛查量表-现症和终生版本土耳其语适应性和康纳父母评定量表进行评估。此外，还采集了血样并测量了天然巯基、总巯基、二硫键和铜蓝蛋白水平。在 ADHD 组中，天然巯基、总巯基和二硫键水平明显低于对照组。铜蓝蛋白水平在 ADHD 组和对照组之间无显著差异。总巯基和天然巯基水平与康纳注意力不集中和多动分量表的评分呈负相关；总巯基与 ADHD 指数呈负相关。ADHD 儿童的巯基-二硫键平衡受损，与症状严重程度有关。氧化应激平衡可能在 ADHD 中起作用。
