硼中子俘获治疗中切伦科夫辐射的发射及潜在应用分析：蒙特卡罗模拟研究

Analysis on the emission and potential application of Cherenkov radiation in boron neutron capture therapy: A Monte Carlo simulation study.

作者信息

Shu Di-Yun, Geng Chang-Ran, Tang Xiao-Bin, Gong Chun-Hui, Shao Wen-Cheng, Ai Yao

机构信息

Nanjing University of Aeronautics and Astronautics, Department of Nuclear Science and Engineering, 29 Yudao St., Nanjing 210016, China.

Nanjing University of Aeronautics and Astronautics, Department of Nuclear Science and Engineering, 29 Yudao St., Nanjing 210016, China; Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, 29 Yudao St., Nanjing 210016, China.

出版信息

Appl Radiat Isot. 2018 Jul;137:219-224. doi: 10.1016/j.apradiso.2018.04.012. Epub 2018 Apr 6.

DOI:10.1016/j.apradiso.2018.04.012

PMID:29655128

Abstract

This paper was aimed to explore the physics of Cherenkov radiation and its potential application in boron neutron capture therapy (BNCT). The Monte Carlo toolkit Geant4 was used to simulate the interaction between the epithermal neutron beam and the phantom containing boron-10. Results showed that Cherenkov photons can only be generated from secondary charged particles of gamma rays in BNCT, in which the 2.223 MeV prompt gamma rays are the main contributor. The number of Cherenkov photons per unit mass generated in the measurement region decreases linearly with the increase of boron concentration in both water and tissue phantom. The work presented the fundamental basis for applications of Cherenkov radiation in BNCT.

摘要

本文旨在探索切伦科夫辐射的物理特性及其在硼中子俘获疗法（BNCT）中的潜在应用。使用蒙特卡罗工具包Geant4模拟超热中子束与含硼-10体模之间的相互作用。结果表明，在BNCT中，切伦科夫光子只能由伽马射线的次级带电粒子产生，其中2.223兆电子伏瞬发伽马射线是主要贡献者。在测量区域每单位质量产生的切伦科夫光子数量，在水和组织体模中均随硼浓度的增加而线性减少。这项工作为切伦科夫辐射在BNCT中的应用提供了基础依据。