Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Biomed Pharmacother. 2018 Jul;103:248-252. doi: 10.1016/j.biopha.2018.03.149. Epub 2018 Apr 24.
The present study was to evaluate the effects of paeoniflorin (PA) on systemic lupus erythematosus induced depressive behaviors. 10 wild type mice and 20 MRL/lpr mice were applied for the research. The animals were randomly assigned to wild type, MRL/lpr group and MRL/lpr + PA group. PA restored depressive-like behaviors, such as sucrose consumption, immobile time in the tail suspension tests (TST) and forced swimming tests (FST). PA significantly decreased the levels of interleukin-6 (IL-6), IL-1β, tumor necrosis factor-α (TNF-α) in serum and hippocampus of MRL/lpr mice. Western blot results demonstrated PA inhibited the levels of HMGB1/TLR4/NF-κB pathway. The findings showed that PA was beneficial for the prevention of systemic lupus erythematosus induced depressive behaviors, which possibly by suppressing HMGB1/TLR4/NF-κB pathway.
本研究旨在评估芍药苷（PA）对红斑狼疮诱导抑郁行为的影响。应用 10 只野生型小鼠和 20 只 MRL/lpr 小鼠进行研究。将动物随机分为野生型、MRL/lpr 组和 MRL/lpr+PA 组。PA 恢复了抑郁样行为，如蔗糖消耗、悬尾试验（TST）和强迫游泳试验（FST）中的不动时间。PA 显著降低了 MRL/lpr 小鼠血清和海马中白细胞介素 6（IL-6）、IL-1β、肿瘤坏死因子-α（TNF-α）的水平。Western blot 结果表明，PA 抑制了 HMGB1/TLR4/NF-κB 通路的水平。研究结果表明，PA 有利于预防红斑狼疮诱导的抑郁行为，其可能通过抑制 HMGB1/TLR4/NF-κB 通路。
