全身型重症肌无力：分类、临床表现、自然史及流行病学
Generalized Myasthenia Gravis: Classification, Clinical Presentation, Natural History, and Epidemiology.
作者信息
Hehir Michael K, Silvestri Nicholas J
机构信息
Department of Neurosciences, Larner College of Medicine at the University of Vermont, University of Vermont, 1 South Prospect Street, Burlington, VT 05401, USA.
Department of Neurology, University at Buffalo Jacobs School of Medicine & Biomedical Sciences, 1010 Main Street, Buffalo, New York 14202, USA.
出版信息
Neurol Clin. 2018 May;36(2):253-260. doi: 10.1016/j.ncl.2018.01.002.
Myasthenia gravis (MG) is a rare disease, but the most common disorder of the neuromuscular junction. It is the prototypic autoimmune disease most commonly caused by antibodies to the acetylcholine receptor (AChR) leading to characteristic fatigable weakness of the ocular, bulbar, respiratory, axial, and limb muscles. The majority of patients with MG first present with ocular symptoms. Most patients with MG will experience at least 1 exacerbation of symptoms throughout the course of their illness. This article will cover the epidemiology, clinical presentation, classification, and natural history of MG.
重症肌无力（MG）是一种罕见疾病，但却是神经肌肉接头处最常见的病症。它是典型的自身免疫性疾病，最常见的病因是针对乙酰胆碱受体（AChR）的抗体，导致眼部、延髓、呼吸、躯干及肢体肌肉出现特征性的易疲劳性肌无力。大多数重症肌无力患者最初表现为眼部症状。大多数重症肌无力患者在病程中至少会经历一次症状加重。本文将涵盖重症肌无力的流行病学、临床表现、分类及自然病史。
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