Barnett Carolina, Herbelin Laura, Dimachkie Mazen M, Barohn Richard J
Neurology (Medicine), University of Toronto, University Health Network, Toronto, Ontario, Canada.
Department of Neurology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.
Neurol Clin. 2018 May;36(2):339-353. doi: 10.1016/j.ncl.2018.01.006.
In this article we provide an overview of health-related outcome measurement-to better understand what different outcomes used in myasthenia actually measure-and to provide some guidance when choosing measures based on the clinical context and question. In myasthenia, the most commonly used outcome measures are aimed at assessing the signs and symptoms. In this review, we provide a summary of the most commonly used outcome measures. We discuss instruments that gauge disease overall health impact, such as on disability and quality of life. Finally, we discuss other relevant outcomes such as steroid-sparing effects and the role of surrogate markers.
在本文中，我们概述了与健康相关的结果测量，以便更好地理解重症肌无力中使用的不同结果实际测量的内容，并在根据临床背景和问题选择测量方法时提供一些指导。在重症肌无力中，最常用的结果测量旨在评估体征和症状。在本综述中，我们总结了最常用的结果测量方法。我们讨论了评估疾病对整体健康影响的工具，如对残疾和生活质量的影响。最后，我们讨论了其他相关结果，如类固醇节省效应和替代标志物的作用。
