Lookingbill D P, Demers L M, Tigelaar R E, Shalita A R
Department of Medicine, College of Medicine, Pennsylvania State University, Hershey.
Arch Dermatol. 1988 Apr;124(4):540-3.
Sebaceous glands are stimulated by androgens and can convert them to more active forms. Isotretinoin, however, has a profound inhibitory effect on sebaceous gland size and function. This study evaluated the effect of isotretinoin on serum levels of precursor and tissue-derived androgens. Twenty-four subjects (15 men and nine women) were treated for 20 weeks with 1 mg/kg/d of isotretinoin. Serum samples were obtained at baseline, 8, 16, and 24 weeks, and assayed for precursor androgens--total testosterone (TT), free testosterone (free T), dehydroepiandrosterone (DHEA), dehydroepiandrosterone-sulfate (DHEA-S); and tissue androgens--dihydrotestosterone (DHT), and its metabolite, 3 alpha-androstanediol glucuronide (3 alpha-diol G). Isotretinoin had no meaningful effects on precursor androgens, except for producing an elevation of free T in women. In contrast, isotretinoin produced depressions in the serum levels of DHT and 3 alpha-diol G in women and in 3 alpha-diol G in men. These decreases are believed to be the result, rather than the cause, of a reduction in the size of the sebaceous glands: The magnitude of the observed decreases may represent the amount of tissue-derived androgens that sebaceous glands normally contribute to the circulating pool.
皮脂腺受雄激素刺激，并可将其转化为更具活性的形式。然而，异维A酸对皮脂腺的大小和功能具有显著的抑制作用。本研究评估了异维A酸对血清中前体雄激素和组织来源雄激素水平的影响。24名受试者（15名男性和9名女性）接受了为期20周的异维A酸治疗，剂量为1mg/kg/d。在基线、第8周、第16周和第24周采集血清样本，检测前体雄激素——总睾酮（TT）、游离睾酮（游离T）、脱氢表雄酮（DHEA）、硫酸脱氢表雄酮（DHEA-S）；以及组织雄激素——双氢睾酮（DHT）及其代谢产物3α-雄烷二醇葡萄糖醛酸苷（3α-二醇G）。异维A酸对前体雄激素没有显著影响，不过女性的游离T有所升高。相比之下，异维A酸使女性血清中DHT和3α-二醇G的水平降低，男性血清中3α-二醇G的水平降低。这些降低被认为是皮脂腺大小减小的结果而非原因：观察到的降低幅度可能代表了皮脂腺通常向循环池中贡献的组织来源雄激素的量。
