Lookingbill D P, Horton R, Demers L M, Egan N, Marks J G, Santen R J
J Am Acad Dermatol. 1985 Mar;12(3):481-7. doi: 10.1016/s0190-9622(85)70067-9.
Precursor and target tissue-produced androgens were measured in the plasma of eighteen women with mild to moderate acne. Mean plasma levels of the precursor androgens (total testosterone, free testosterone, androstenedione, and dehydroepiandrosterone sulfate) wer similar to levels in a group of carefully selected acne-free and hirsute-free, age-matched female controls. In contrast, plasma 3 alpha-androstanediol glucuronide (3 alpha-diol G) values were elevated in 13 of the patients, with a mean value for the entire group nearly threefold that of the normal controls (117 vs 43 ng/dl; p less than 0.001). These results support the concept that target tissue androgen production plays an important hormonal role in the pathogenesis of acne in women and that plasma 3 alpha-diol G may be the most sensitive marker of this process.
在18名患有轻至中度痤疮的女性血浆中检测了前体和靶组织产生的雄激素。前体雄激素（总睾酮、游离睾酮、雄烯二酮和硫酸脱氢表雄酮）的平均血浆水平与一组精心挑选的无痤疮、无多毛且年龄匹配的女性对照组相似。相比之下，13名患者的血浆3α-雄烷二醇葡萄糖醛酸苷（3α-二醇G）值升高，整个组的平均值几乎是正常对照组的三倍（117对43 ng/dl；p<0.001）。这些结果支持以下概念：靶组织雄激素生成在女性痤疮发病机制中起重要的激素作用，血浆3α-二醇G可能是这一过程最敏感的标志物。
