暴食症和病态肥胖与大脑中μ-阿片受体的可用性降低有关。
Binge eating disorder and morbid obesity are associated with lowered mu-opioid receptor availability in the brain.
机构信息
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Neurology, University of Turku, Turku, Finland; Turku PET Centre, University of Turku, Turku, Finland; Division of Clinical Neurosciences, Turku University Hospital, Turku, Finland.
Turku PET Centre, University of Turku, Turku, Finland.
出版信息
Psychiatry Res Neuroimaging. 2018 Jun 30;276:41-45. doi: 10.1016/j.pscychresns.2018.03.006. Epub 2018 Mar 9.
Both morbid obesity and binge eating disorder (BED) have previously been linked with aberrant brain opioid function. Behaviorally these two conditions are however different suggesting also differences in neurotransmitter function. Here we directly compared mu-opioid receptor (MOR) availability between morbidly obese and BED subjects. Seven BED and nineteen morbidly obese (non-BED) patients, and thirty matched control subjects underwent positron emission tomography (PET) with MOR-specific ligand [C]carfentanil. Both subjects with morbid obesity and BED had widespread reduction in [C]carfentanil binding compared to control subjects. However, there was no significant difference in brain MOR binding between subjects with morbid obesity and BED. Thus, our results indicate that there is common brain opioid abnormality in behaviorally different eating disorders involving obesity.
病态肥胖和暴食障碍（BED）以前都与异常的大脑阿片功能有关。然而，从行为上看，这两种情况有所不同，提示神经递质功能也存在差异。在这里，我们直接比较了病态肥胖和 BED 患者之间的μ-阿片受体（MOR）的可用性。七名 BED 患者和十九名病态肥胖（非 BED）患者以及三十名匹配的对照者接受了 MOR 特异性配体 [C]carfentanil 的正电子发射断层扫描（PET）。与对照组相比，肥胖症和 BED 患者的 [C]carfentanil 结合广泛减少。然而，肥胖症和 BED 患者之间的大脑 MOR 结合没有显著差异。因此，我们的结果表明，涉及肥胖的行为不同的饮食失调中存在常见的大脑阿片类异常。
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