Zimecki M, Pierce-Cretel A, Spik G, Wieczorek Z
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.
Arch Immunol Ther Exp (Warsz). 1987;35(3):351-60.
The immunoregulatory properties of several proteins, isolated from human milk, were investigated. Secretory component and galactothermin exhibited immunoregulatory activities in the in vivo and in vitro assays, generating helper cells, changing the ARFC levels and the resistance of thymocytes to hydrocortisone (HC). In addition, the immunoregulatory action of the P protein and its four fractions was studied. The bulk of the activity was found in the fraction II and III. The results suggest that the postneonatal development of the mammalian immune system is under the surveillance of various immunoregulatory proteins contained in maternal secretory fluids.
对从人乳中分离出的几种蛋白质的免疫调节特性进行了研究。分泌成分和半乳糖热稳定素在体内和体外试验中均表现出免疫调节活性，可产生辅助细胞，改变活性玫瑰花结形成细胞（ARFC）水平以及胸腺细胞对氢化可的松（HC）的抵抗力。此外，还研究了P蛋白及其四个组分的免疫调节作用。大部分活性存在于组分II和III中。结果表明，哺乳动物免疫系统的新生儿后期发育受到母体分泌液中各种免疫调节蛋白的监测。
