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T淋巴细胞亚群的集落形成。IV. 氢化可的松对人和小鼠T细胞亚群的抑制作用。

Colony formation by subpopulations of T lymphocytes. IV. Inhibitory effect of hydrocortisone on human and murine T cell subsets.

作者信息

Claësson M H, Röpke C

出版信息

Clin Exp Immunol. 1983 Nov;54(2):554-60.

PMID:6228355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1535909/
Abstract

The sensitivity of human T lymphocyte colony formation to hydrocortisone (HCS) was studied in the presence and absence of an exogenous source of interleukin-2(IL-2). In the presence of IL-2, T colony formation by T inducer/helper (Th) cells was found to be 100-fold more resistant to the inhibitory effect of HCS in vitro than colony formation by T suppressor/cytotoxic (Tsc) cells, the IC50 values for HCS being 10(-4)M and 10(-6)M, respectively. In the absence of IL-2,Tsc cells do not form colonies and T cell colony formation by Th cells is inhibited 50% by less than 5 x 10(-8)M HCS. T lymphocyte colony formation by murine cortical thymocytes in vitro was inhibited by physiological concentrations of HCS in vitro, the IC50 value being 2 x 10(-8)M HCS. T cell colony formation by medullary thymocytes and peripheral lymphocytes was found to be 100-fold more resistant to HCS than control cells, the IC50 value being 2 x 10(-6)M HCS.

摘要

在有和没有外源性白细胞介素-2（IL-2）的情况下，研究了人T淋巴细胞集落形成对氢化可的松（HCS）的敏感性。在有IL-2存在时，发现T诱导/辅助（Th）细胞形成T集落对HCS体外抑制作用的抗性比T抑制/细胞毒性（Tsc）细胞形成集落高100倍，HCS的IC50值分别为10^(-4)M和10^(-6)M。在没有IL-2时，Tsc细胞不形成集落，Th细胞形成T细胞集落被小于5×10^(-8)M的HCS抑制50%。小鼠皮质胸腺细胞体外T淋巴细胞集落形成在体外被生理浓度的HCS抑制，IC50值为2×10^(-8)M HCS。发现髓质胸腺细胞和外周淋巴细胞形成T细胞集落对HCS的抗性比对照细胞高100倍，IC50值为2×10^(-6)M HCS。

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Inhibition of human T lymphocyte colony formation by methylprednisolone.甲基泼尼松龙对人T淋巴细胞集落形成的抑制作用。
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Colony-forming lymphocytes in man. I. In vivo effect of hydrocortisone on phytohaemagglutinin-induced T cell colony formation.人类中的集落形成淋巴细胞。I. 氢化可的松对植物血凝素诱导的T细胞集落形成的体内效应。
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