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Clin Exp Immunol. 1983 Nov;54(2):554-60.
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本文引用的文献

1
THE PATTERN OF LYMPHOPOIESIS IN THE MOUSE THYMUS AFTER CORTISONE ADMINISTRATION OR ADRENALECTOMY.注射可的松或肾上腺切除术后小鼠胸腺中的淋巴细胞生成模式
Aust J Exp Biol Med Sci. 1963 Dec;41:637-49. doi: 10.1038/icb.1963.53.
2
Inhibition of human T lymphocyte colony formation by methylprednisolone.甲基泼尼松龙对人T淋巴细胞集落形成的抑制作用。
Clin Exp Immunol. 1981 Oct;46(1):206-13.
3
Colony-forming lymphocytes in man. I. In vivo effect of hydrocortisone on phytohaemagglutinin-induced T cell colony formation.人类中的集落形成淋巴细胞。I. 氢化可的松对植物血凝素诱导的T细胞集落形成的体内效应。
Clin Exp Immunol. 1981 Sep;45(3):557-61.
4
Identification and characterization of immature thymocytes responsive to T cell growth factor.
Eur J Immunol. 1981 Jan;11(1):1-7. doi: 10.1002/eji.1830110102.
5
Biochemical separation of interleukin 2.白细胞介素2的生化分离
J Immunol Methods. 1980;39(3):185-201. doi: 10.1016/0022-1759(80)90055-1.
6
Mitogenic effects of partially purified interleukin 2 on thymocyte subpopulations and spleen t cells of the mouse.部分纯化的白细胞介素2对小鼠胸腺细胞亚群和脾T细胞的促有丝分裂作用。
Eur J Immunol. 1980 Sep;10(9):702-7. doi: 10.1002/eji.1830100909.
7
Human T lymphocytes grown in T-cell growth factor: functional attributes in MLC, CML, PLT and allogeneic suppression.在T细胞生长因子中培养的人T淋巴细胞：在混合淋巴细胞培养、慢性淋巴细胞白血病、血小板输注及同种异体抑制中的功能特性
Immunology. 1981 Apr;42(4):529-40.
8
Hydrocortisone sensitivity of human in vitro antibody response: different sensitivity of the specific and the nonspecific B-cell responses induced by the same agent.氢化可的松对人体外抗体应答的敏感性：同一因子诱导的特异性和非特异性B细胞应答的不同敏感性。
Clin Immunol Immunopathol. 1981 Jan;18(1):68-75. doi: 10.1016/0090-1229(81)90009-x.
9
Corticosteroid-mediated immunoregulation in man.人类中皮质类固醇介导的免疫调节。
Immunol Rev. 1982;65:133-55. doi: 10.1111/j.1600-065x.1982.tb00431.x.
10
The in vitro generation of suppressor lymphocytes involves interactions between PNA+ and PNA- thymocyte populations.抑制性淋巴细胞的体外生成涉及PNA⁺和PNA⁻胸腺细胞群体之间的相互作用。
Immunology. 1982 Aug;46(4):697-704.

T淋巴细胞亚群的集落形成。IV. 氢化可的松对人和小鼠T细胞亚群的抑制作用。

Colony formation by subpopulations of T lymphocytes. IV. Inhibitory effect of hydrocortisone on human and murine T cell subsets.

作者信息

Claësson M H, Röpke C

出版信息

Clin Exp Immunol. 1983 Nov;54(2):554-60.

PMID:6228355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1535909/
Abstract

The sensitivity of human T lymphocyte colony formation to hydrocortisone (HCS) was studied in the presence and absence of an exogenous source of interleukin-2(IL-2). In the presence of IL-2, T colony formation by T inducer/helper (Th) cells was found to be 100-fold more resistant to the inhibitory effect of HCS in vitro than colony formation by T suppressor/cytotoxic (Tsc) cells, the IC50 values for HCS being 10(-4)M and 10(-6)M, respectively. In the absence of IL-2,Tsc cells do not form colonies and T cell colony formation by Th cells is inhibited 50% by less than 5 x 10(-8)M HCS. T lymphocyte colony formation by murine cortical thymocytes in vitro was inhibited by physiological concentrations of HCS in vitro, the IC50 value being 2 x 10(-8)M HCS. T cell colony formation by medullary thymocytes and peripheral lymphocytes was found to be 100-fold more resistant to HCS than control cells, the IC50 value being 2 x 10(-6)M HCS.

摘要

在有和没有外源性白细胞介素-2（IL-2）的情况下，研究了人T淋巴细胞集落形成对氢化可的松（HCS）的敏感性。在有IL-2存在时，发现T诱导/辅助（Th）细胞形成T集落对HCS体外抑制作用的抗性比T抑制/细胞毒性（Tsc）细胞形成集落高100倍，HCS的IC50值分别为10^(-4)M和10^(-6)M。在没有IL-2时，Tsc细胞不形成集落，Th细胞形成T细胞集落被小于5×10^(-8)M的HCS抑制50%。小鼠皮质胸腺细胞体外T淋巴细胞集落形成在体外被生理浓度的HCS抑制，IC50值为2×10^(-8)M HCS。发现髓质胸腺细胞和外周淋巴细胞形成T细胞集落对HCS的抗性比对照细胞高100倍，IC50值为2×10^(-6)M HCS。