皮脂分泌与痤疮的遗传控制——一项双胞胎研究

Genetic control of sebum excretion and acne--a twin study.

作者信息

Walton S, Wyatt E H, Cunliffe W J

机构信息

Department of Dermatology, Hull Royal Infirmary, U.K.

出版信息

Br J Dermatol. 1988 Mar;118(3):393-6. doi: 10.1111/j.1365-2133.1988.tb02433.x.

DOI:10.1111/j.1365-2133.1988.tb02433.x

PMID:2965597

Abstract

Sebum excretion and acne grades were measured in 20 pairs each of identical and non-identical like-sex twins. The identical twins had virtually identical rates of sebum excretion (P greater than 0.05), but they had a significantly different degree of acne severity (P less than 0.01). The non-identical twins had significantly different sebum excretion rates (P less than 0.01) and acne grades (P less than 0.01). These findings suggest that sebum excretion is under genetic control and the development of clinical lesions is modified by environmental factors.

摘要

对20对同卵和异卵同性双胞胎分别测量皮脂分泌和痤疮分级。同卵双胞胎的皮脂分泌率几乎相同（P>0.05），但他们的痤疮严重程度有显著差异（P<0.01）。异卵双胞胎的皮脂分泌率（P<0.01）和痤疮分级（P<0.01）有显著差异。这些发现表明皮脂分泌受遗传控制，临床皮损的发生受环境因素影响。