Romańska-Gocka Krystyna, Woźniak Magdalena, Kaczmarek-Skamira Elżbieta, Zegarska Barbara
Department of Cosmetology and Esthetic Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
Postepy Dermatol Alergol. 2016 Dec;33(6):416-420. doi: 10.5114/ada.2016.63880. Epub 2016 Dec 2.
Acne in adults is a chronic, increasingly common disease, especially among women. It differs in pathogenesis and clinical presentation from adolescent acne. Acne in adults is associated with Western diet, defined as high consumption of milk, high glycemic load and high calorie intake. Metabolic signals of this diet result in a significant increase in insulin/insulin growth factor 1 serum level and consequently in the molecular interplay of mammalian target of rapamycin complex 1 kinase (mTORC1)/forkhead box protein 1 (FoxO1) mediated nutrient signaling, leading to increased proliferation of keratinocytes, increased lipogenesis and sebum production and finally to aggravation of acne.
成人痤疮是一种慢性且日益常见的疾病，尤其在女性中更为普遍。其发病机制和临床表现与青少年痤疮有所不同。成人痤疮与西方饮食有关，西方饮食的特点是牛奶摄入量高、血糖负荷高和热量摄入高。这种饮食的代谢信号会导致胰岛素/胰岛素生长因子1血清水平显著升高，进而导致雷帕霉素复合物1激酶（mTORC1）/叉头框蛋白1（FoxO1）介导的营养信号分子相互作用增强，导致角质形成细胞增殖增加、脂肪生成和皮脂分泌增加，最终加重痤疮。
