经颅交流电刺激（tACS）介导的听觉稳态反应调制，如通过脑磁图（MEG）所见。
tACS-mediated modulation of the auditory steady-state response as seen with MEG.
作者信息
Hyvärinen Petteri, Choi Dawoon, Demarchi Gianpaolo, Aarnisalo Antti A, Weisz Nathan
机构信息
Department of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Biomedicum Helsinki 1, P.O. Box 220, FI-00029 HUS, Finland; Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Finland.
Department of Psychology, The University of British Columbia, Canada.
出版信息
Hear Res. 2018 Jul;364:90-95. doi: 10.1016/j.heares.2018.03.023. Epub 2018 Mar 28.
BACKGROUND
Previous studies have shown that transcranial electrical stimulation can be successfully applied during simultaneous MEG measurements. In particular, using beamforming they have established that changes of stimulus induced as well as evoked activity can be inspected during transcranial alternating current stimulation (tACS).
OBJECTIVE/HYPOTHESIS: We studied tACS-mediated changes of the auditory steady-state response (ASSR), hypothesizing that-due to the putatively inhibitory role of alpha oscillations-these evoked responses would be diminished.
METHODS
We compared ASSRs in conditions with and without 12-Hz and 6.5-Hz sinusoidal 1.5 mA tACS, applied bilaterally over temporal areas. Source-level activity was estimated using a linearly constrained minimum variance beamformer and compared across tACS conditions using paired t-tests following a condition-internal normalization procedure.
CONCLUSIONS
By separating the electrical and auditory stimulation to non-overlapping parts of the frequency spectrum, we were able to compare auditory-evoked steady-state activity across tACS conditions. We observed a significant decrease in normalized ASSR power in the 12-Hz tACS condition, illustrating that tACS could induce immediate changes in auditory evoked activity. This study sets a methodology to further interrogate the causal roles of oscillatory dynamics in auditory cortices, as well as suggests perspectives for employing tACS in clinical contexts.
背景
先前的研究表明，经颅电刺激可以在同时进行脑磁图测量时成功应用。特别是，他们使用波束形成技术证实，在经颅交流电刺激（tACS）期间，可以检测到刺激诱发活动以及诱发反应的变化。
目的/假设：我们研究了tACS介导的听觉稳态反应（ASSR）的变化，假设由于α振荡可能具有抑制作用，这些诱发反应会减弱。
方法
我们比较了在双侧颞区施加1.5 mA的12 Hz和6.5 Hz正弦tACS与不施加tACS条件下的ASSR。使用线性约束最小方差波束形成器估计源水平活动，并在条件内部归一化程序后，使用配对t检验比较不同tACS条件下的活动。
结论
通过将电刺激和听觉刺激分离到频谱的不重叠部分，我们能够比较不同tACS条件下的听觉诱发稳态活动。我们观察到在12 Hz tACS条件下，归一化ASSR功率显著降低，说明tACS可以立即诱发听觉诱发活动的变化。本研究建立了一种方法，以进一步探究振荡动力学在听觉皮层中的因果作用，并为在临床环境中应用tACS提供了思路。
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