School of Biotechnology, National Institute of Technology Calicut, Calicut, 673601, India.
School of Biotechnology, National Institute of Technology Calicut, Calicut, 673601, India.
Neurosci Biobehav Rev. 2018 Jul;90:104-114. doi: 10.1016/j.neubiorev.2018.04.005. Epub 2018 Apr 12.
Post-stroke depression (PSD) is the most common mental health issue, afflicting around 33% of stroke survivors. PSD has a negative impact on the rehabilitation, recuperation of motor and cognitive deficits following stroke and significantly increases the chances of relapsing neurovascular events. It has been demonstrated that biological and psychological factors have a significant role in PSD. Numerous endeavors have been made to discover the risk factors and predictors of PSD. Screening and diagnosis also have gained attention; however, a suitable tool is yet to be developed. Medications are chosen based on their viability and reaction profile in the patients. Besides pharmacotherapy, psychotherapy treatment is also highly valued by both psychiatrists and stroke patients. Additional research is needed to examine the pathophysiology of PSD. This review attempts to highlight the existing evidence and gaps in the present knowledge of the predictors of PSD, incidence, prevalence, and etiology. Further, it also discusses the screening and diagnostic approaches, therapeutic modalities and management of PSD and the impact of pre-stroke depression on PSD.
脑卒中后抑郁（PSD）是最常见的心理健康问题，影响约 33%的脑卒中幸存者。PSD 对脑卒中后运动和认知缺陷的康复和恢复有负面影响，并显著增加神经血管事件复发的几率。已经证明，生物和心理因素在 PSD 中起着重要作用。人们已经做出了许多努力来发现 PSD 的风险因素和预测因素。筛查和诊断也受到了关注；然而，合适的工具尚未开发出来。药物的选择取决于它们在患者中的可行性和反应谱。除了药物治疗外，心理治疗也深受精神科医生和脑卒中患者的重视。需要进一步的研究来检查 PSD 的病理生理学。本综述试图强调 PSD 的预测因素、发生率、患病率和病因学的现有证据和差距。此外，它还讨论了 PSD 的筛查和诊断方法、治疗方式和管理以及脑卒中前抑郁对 PSD 的影响。
