Li Qiaoling, Zhang Yuejuan, Wang Xiaoqian, Dai Lin, Zhao Wenli
Graduate School, Hunan University of Chinese Medicine, Changsha, China.
Department of Nursing, The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, China.
Front Cell Infect Microbiol. 2025 May 1;15:1444793. doi: 10.3389/fcimb.2025.1444793. eCollection 2025.
Evidence of changes in the composition and function of the gut microbiota (GM) in post-stroke depression (PSD) patients is gradually accumulating. This study aimed to systematically evaluate the relationship between PSD and GM.
We searched in PubMed, Web of Science, Embase, Cochrane databases, Wangfang, VIP, CBM, and CNKI from the establishment of the database to April 17, 2024, and systematic review and meta-analysis were performed to investigate the differences of GM between patients with PSD spectrum and healthy controls (HC) or stroke spectrum.
There were 14 studies consisting a total of 1,556 individuals included in the meta-analysis. The pooled results showed that PSD spectrum demonstrated significantly increased α diversity as indexed by Chao1 index, ACE indexes, Shannon index, and Simpson index as compared to HC. Additionally, stroke spectrum significantly increased α diversity as indexed by Simpson index compared to PSD. Furthermore, the pooled estimation of relative abundance showed that , , and in PSD patients were significantly higher than those in the HC group, while the abundance of was higher in the HC group. Moreover, significant differences in GM were observed between PSD patients and HC at the family and genus levels.
This study found that the α diversity of PSD patients was higher than that of HC. Moreover, there were also differences in the distribution of GM at the phylum, family, and genus levels, respectively. At the same time, the level of in PSD patients was lower than that in the stroke group.
https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024582708.
中风后抑郁症（PSD）患者肠道微生物群（GM）的组成和功能变化的证据正在逐渐积累。本研究旨在系统评价PSD与GM之间的关系。
我们检索了从数据库建立至2024年4月17日的PubMed、Web of Science、Embase、Cochrane数据库、万方、维普、中国生物医学文献数据库和中国知网，并进行系统评价和荟萃分析，以研究PSD谱系患者与健康对照（HC）或中风谱系患者之间GM的差异。
荟萃分析纳入了14项研究，共1556名个体。汇总结果显示，与HC相比，PSD谱系的Chao1指数、ACE指数、香农指数和辛普森指数所衡量的α多样性显著增加。此外，与PSD相比，中风谱系的辛普森指数所衡量的α多样性显著增加。此外，相对丰度的汇总估计显示，PSD患者的 、 和 显著高于HC组，而HC组的 丰度更高。此外，在科和属水平上，PSD患者与HC之间的GM存在显著差异。
本研究发现PSD患者的α多样性高于HC。此外，在门、科和属水平上，GM的分布也存在差异。同时，PSD患者的 水平低于中风组。
