吲哚美辛可部分逆转移植物抗宿主病小鼠来源的天然抑制细胞对细胞毒性T细胞生成的抑制作用。
Suppression of cytotoxic T-cell generation by natural suppressor cells from mice with GVHD is partially reversed by indomethacin.
作者信息
Choi K L, Maier T, Holda J H, Claman H N
机构信息
Department of Medicine, University of Colorado Health Sciences Center, Denver 80262.
出版信息
Cell Immunol. 1988 Apr 1;112(2):271-8. doi: 10.1016/0008-8749(88)90297-3.
Natural suppressor cells from the spleens of mice with graft-versus-host disease produced across minor histocompatibility barriers inhibit the in vitro generation of alloreactive cytotoxic T lymphocytes by spleen cells from normal mice. The mechanism of natural suppression was studied; suppression does not require direct cell contact with targets. Exogenous interleukin-2 has no effect in reversing suppression while indomethacin partially reverses the suppression mediated by natural suppressor cells.
通过次要组织相容性屏障产生移植物抗宿主病的小鼠脾脏中的天然抑制细胞，可抑制正常小鼠脾脏细胞在体外产生同种异体反应性细胞毒性T淋巴细胞。对天然抑制的机制进行了研究；抑制作用不需要与靶细胞直接接触。外源性白细胞介素-2对逆转抑制作用无效，而吲哚美辛可部分逆转天然抑制细胞介导的抑制作用。
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