Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300000, China.
J Affect Disord. 2018 Aug 1;235:150-154. doi: 10.1016/j.jad.2018.04.036. Epub 2018 Apr 6.
Abnormal neural activity has been observed in patients with somatization disorder (SD), especially in brain regions of the default-mode network (DMN). In this study, a coherence-based regional homogeneity (Cohe-ReHo) approach was used to detect abnormal regional synchronization in patients with SD, which might be used to differentiate the patients from the controls.
We recruited 25 patients with SD and 28 healthy controls. The imaging data of the participants were analyzed using the Cohe-ReHo approach. LIBSVM (a library for support vector machines) was utilized to verify whether abnormal Cohe-ReHo values could be applied to separate patients with SD from healthy controls.
Compared with healthy controls, patients with SD showed an increased Cohe-ReHo in the left medial prefrontal cortex/anterior cingulate cortex (MPFC/ACC) (t = 5.5017, p < 0.001). No correlations were detected between the increased Cohe-ReHo values and clinical variables of the patients. The Cohe-ReHo values in the left MPFC/ACC could be applied to distinguish patients from controls with a sensitivity and a specificity of 84.00% and 85.71%, respectively.
An increased Cohe-ReHo was observed in the anterior DMN of the patients and could be applied as a marker to distinguish patients from healthy controls. These results highlighted the importance of the DMN in the pathophysiology of SD.
躯体化障碍（SD）患者存在异常的神经活动，尤其是在默认模式网络（DMN）的脑区。在本研究中，我们采用基于相干的局部一致性（Cohe-ReHo）方法来检测 SD 患者的局部同步异常，这可能有助于将患者与对照组区分开来。
我们招募了 25 名 SD 患者和 28 名健康对照者。使用 Cohe-ReHo 方法对参与者的影像学数据进行分析。采用 LIBSVM（支持向量机库）来验证异常的 Cohe-ReHo 值是否可用于区分 SD 患者与健康对照者。
与健康对照组相比，SD 患者的左侧内侧前额叶皮层/前扣带皮层（MPFC/ACC）的 Cohe-ReHo 值增加（t=5.5017，p<0.001）。未检测到患者 Cohe-ReHo 值增加与临床变量之间的相关性。左侧 MPFC/ACC 的 Cohe-ReHo 值可用于区分患者与对照组，其灵敏度和特异性分别为 84.00%和 85.71%。
SD 患者的前 DMN 存在 Cohe-ReHo 值增加，可作为一种标志物将患者与健康对照组区分开来。这些结果强调了 DMN 在 SD 病理生理学中的重要性。
