Guo Pingping, Lang Siyuan, Jiang Muliang, Wang Yifeng, Zeng Zisan, Wen Zuguang, Liu Yikang, Chen Bihong T
Department of Medical Ultrasound, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China.
Department of Radiology, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Front Neurosci. 2021 Oct 6;15:678910. doi: 10.3389/fnins.2021.678910. eCollection 2021.
Brain functional alterations have been observed in children with congenital sensorineural hearing loss (CSNHL). The purpose of this study was to assess the alterations of regional homogeneity in children with CSNHL. Forty-five children with CSNHL and 20 healthy controls were enrolled into this study. Brain resting-state functional MRI (rs-fMRI) for regional homogeneity including the Kendall coefficient consistency (KCC-ReHo) and the coherence-based parameter (Cohe-ReHo) was analyzed and compared between the two groups, i.e., the CSNHL group and the healthy control group. Compared to the healthy controls, children with CSNHL showed increased Cohe-ReHo values in left calcarine and decreased values in bilateral ventrolateral prefrontal cortex (VLPFC) and right dorsolateral prefrontal cortex (DLPFC). Children with CSNHL also had increased KCC-ReHo values in the left calcarine, cuneus, precentral gyrus, and right superior parietal lobule (SPL) and decreased values in the left VLPFC and right DLPFC. Correlations were detected between the ReHo values and age of the children with CSNHL. There were positive correlations between ReHo values in the pre-cuneus/pre-frontal cortex and age ( < 0.05). There were negative correlations between ReHo values in bilateral temporal lobes, fusiform gyrus, parahippocampal gyrus and precentral gyrus, and age ( < 0.05). Children with CSNHL had RoHo alterations in the auditory, visual, motor, and other related brain cortices as compared to the healthy controls with normal hearing. There were significant correlations between ReHo values and age in brain regions involved in information integration and processing. Our study showed promising data using rs-fMRI ReHo parameters to assess brain functional alterations in children with CSNHL.
先天性感音神经性听力损失（CSNHL）患儿已观察到脑功能改变。本研究旨在评估CSNHL患儿局部一致性的改变。45例CSNHL患儿和20名健康对照者纳入本研究。对两组（即CSNHL组和健康对照组）进行脑静息态功能磁共振成像（rs-fMRI）分析，比较包括肯德尔系数一致性（KCC-ReHo）和基于相干性的参数（Cohe-ReHo）的局部一致性。与健康对照组相比，CSNHL患儿左侧距状区的Cohe-ReHo值升高，双侧腹外侧前额叶皮质（VLPFC）和右侧背外侧前额叶皮质（DLPFC）的值降低。CSNHL患儿左侧距状区、楔叶、中央前回和右侧顶上小叶（SPL）的KCC-ReHo值也升高，左侧VLPFC和右侧DLPFC的值降低。检测到CSNHL患儿的ReHo值与年龄之间存在相关性。楔前叶/前额叶皮质的ReHo值与年龄呈正相关（<0.05）。双侧颞叶、梭状回、海马旁回和中央前回的ReHo值与年龄呈负相关（<0.05）。与听力正常的健康对照组相比，CSNHL患儿在听觉、视觉、运动及其他相关脑皮质存在RoHo改变。在参与信息整合和处理的脑区，ReHo值与年龄之间存在显著相关性。我们的研究显示，使用rs-fMRI ReHo参数评估CSNHL患儿脑功能改变的数据很有前景。
