Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi 710071, China.
Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi 710071, China.
J Affect Disord. 2018 Aug 1;235:191-197. doi: 10.1016/j.jad.2018.04.046. Epub 2018 Apr 7.
Premenstrual syndrome (PMS) is characterized by a series of emotional, physical and behavioral symptoms. Although PMS is related to dysfunctions of the central nervous system, the neuropathological mechanism of PMS still has not been clearly established. The aim of this study is to evaluate potential differences in both cortical thickness and subcortical volumes in PMS patients compared to healthy controls (HCs).
Twenty PMS patients and twenty HCs underwent a structural magnetic resonance imaging scan and clinical assessment. Cortical thickness and subcortical volumes were computed using the FreeSurfer image analysis suite. Relationships between cortical thickness/subcortical volumes and the daily rating of severity of problems (DRSP) score were then measured in patients.
Compared to HCs, PMS patients exhibited reduced cortical thickness in the medial prefrontal cortex (MPFC), orbitofrontal cortex (OFC) and insula, and increased subcortical volumes of the amygdala, thalamus and pallidum. Furthermore, negative correlations were detected between the DRSP and cortical thickness in the anterior cingulate cortex and precuneus.
The study is limited by a small sample size and narrow age range of participants.
Our findings indicate that the abnormal morphological changes are mainly implicated in emotional regulation and visceral perception in PMS patients. We hope that our study may contribute to a better understanding of PMS.
经前期综合征（PMS）的特征为一系列情绪、身体和行为症状。尽管 PMS 与中枢神经系统功能障碍有关，但 PMS 的神经病理学机制仍未明确。本研究旨在评估 PMS 患者与健康对照者（HCs）相比皮质厚度和皮质下体积的潜在差异。
20 名 PMS 患者和 20 名 HCs 接受了结构磁共振成像扫描和临床评估。使用 FreeSurfer 图像分析套件计算皮质厚度和皮质下体积。然后，在患者中测量皮质厚度/皮质下体积与每日严重程度评分（DRSP）之间的关系。
与 HCs 相比，PMS 患者的内侧前额叶皮质（MPFC）、眶额皮质（OFC）和岛叶皮质厚度减小，杏仁核、丘脑和苍白球的皮质下体积增加。此外，DRSP 与前扣带回和楔前叶的皮质厚度呈负相关。
该研究受到样本量小和参与者年龄范围窄的限制。
我们的发现表明，异常的形态变化主要与 PMS 患者的情绪调节和内脏感知有关。我们希望我们的研究有助于更好地理解 PMS。
