Carvalho Lucas Senra Correa, Nascimento Osvaldo José Moreira, Rodrigues Luciane Lacerda Franco Rocha, Matta Andre Palma Da Cunha
Department Of Neurology, University Federal Fluminense, Niterói, Brazil.
Department Of Graduate Program In Temporomandibular Disorder, Sao Leopoldo Mandic, Campinas,Brazil.
Eur J Dent. 2018 Jan-Mar;12(1):144-148. doi: 10.4103/ejd.ejd_91_17.
The objectives of this study were to assess the prevalence of temporomandibular disorders (TMDs) in patients with relapsing-remitting multiple sclerosis (MS) and to investigate whether an association exists between the presence of TMD symptoms and the degree of MS-related disability.
In all, 120 individuals were evaluated: 60 patients with a diagnosis of relapsing-remitting MS and 60 age- and sex-matched controls without neurological impairments. A questionnaire recommended by the European Academy of Craniomandibular Disorders for the assessment of TMD symptoms was administered. For those who answered affirmatively to at least one of the questions, the RDC/TMD Axis I instrument was used for a possible classification of TMD subtypes. The Expanded Disability Status Scale (EDSS) was the measure of the degree of MS-related disability.
Fisher's exact test was used to analyze the data. ANOVA was used to detect significant differences between means and to assess whether the factors influenced any of the dependent variables by comparing means from the different groups.
The prevalence of TMD symptoms in patients with MS was 61.7% versus 18.3% in the control group (CG). A diagnosis of TMD was established for 36.7% in the MS group and 3.3% in the CG ( = 0.0001). There were statistically significant differences between degrees of MS-related disability and the prevalence of TMD ( = 0.0288).
The prevalence of both TMD and TMD symptoms was significantly greater in the MS group. EDSS scores and TMD prevalence rates were inversely related.
本研究的目的是评估复发缓解型多发性硬化症（MS）患者颞下颌关节紊乱病（TMDs）的患病率，并调查TMD症状的存在与MS相关残疾程度之间是否存在关联。
共评估了120人：60例诊断为复发缓解型MS的患者和60名年龄及性别匹配、无神经功能障碍的对照者。采用欧洲颅下颌疾病学会推荐的用于评估TMD症状的问卷进行调查。对于至少对其中一个问题回答为肯定的患者，使用RDC/TMD轴I工具对TMD亚型进行可能的分类。扩展残疾状态量表（EDSS）用于衡量MS相关残疾的程度。
采用Fisher精确检验分析数据。方差分析用于检测均值之间的显著差异，并通过比较不同组的均值来评估因素是否影响任何一个因变量。
MS患者中TMD症状的患病率为61.7%，而对照组（CG）为18.3%。MS组中36.7%的患者被诊断为TMD，CG组为3.3%（P = 0.0001）。MS相关残疾程度与TMD患病率之间存在统计学显著差异（P = 0.0288）。
MS组中TMD及TMD症状的患病率均显著更高。EDSS评分与TMD患病率呈负相关。
