Yılmaz Ebru, Yılmaz Ayhan, Aslan Ahmet, Inan Ibrahim, Evren Mujgan Calıskan, Tekesin Kemal
Department of Radiology, Gaziosmanpaşa Taksim Training and Research Hospital, Istanbul, Turkey.
Department of Radiology, Bezmialem Vakif University Hospital, Istanbul, Turkey.
Pol J Radiol. 2017 Nov 17;82:664-669. doi: 10.12659/PJR.902596. eCollection 2017.
To investigate the diagnostic performance of the elastography-based strain index ratio in the differential diagnosis of malignant and benign breast lesions.
MATERIAL/METHODS: Seventy-nine breast masses that were classified as BI-RADS category 3, 4, and 5 on B-mode ultrasonography (US) were further prospectively evaluated by real-time sonoelastography (RTE). To obtain an optimal cut-off value of the strain ratio for differentiating between malignant and benign breast lesions, RTE findings were compared with histopathology of core needle biopsy samples or with ultrasound follow-up data of the analyzed masses.
Seventy-nine breast lesions [BI-RADS category 3 (n=15), BI-RADS category 4 (n=34), and BI-RADS category 5 (n=30)] were classified as malignant (n=36) or benign (n=43). The mean strain index value was 6.59±3.44 (range 0.6-14) for malignant lesions and 2.79±2.16 (range 0.6-8.7) for benign lesions, respectively (p<0.05). As regards the detection of malignant lesions, US was characterized by sensitivity and specificity of 100% (CI 95%; 88-100) and 90% (CI 95%; 76-97), respectively. When an optimal value of the strain ratio (4.25) was obtained by ROC curve analysis, the sensitivity and specificity for diagnosing malignant lesions were 86% (CI 95%; 70-95) and 76% (CI 95%; 60-87), respectively.
RTE can play an important role in the differentiation between malignant and benign breast masses, but it should be used in conjunction with ultrasonography.
探讨基于弹性成像的应变指数比在乳腺良恶性病变鉴别诊断中的诊断性能。
材料/方法：对79例在B型超声（US）检查中被分类为BI-RADS 3、4和5类的乳腺肿块进行实时超声弹性成像（RTE）前瞻性评估。为获得用于区分乳腺良恶性病变的应变比最佳临界值，将RTE检查结果与粗针活检样本的组织病理学结果或所分析肿块的超声随访数据进行比较。
79例乳腺病变[BI-RADS 3类（n = 15）、BI-RADS 4类（n = 34）和BI-RADS 5类（n = 30）]被分类为恶性（n = 36）或良性（n = 43）。恶性病变的平均应变指数值分别为6.59±3.44（范围0.6 - 14），良性病变为2.79±2.16（范围0.6 - 8.7）（p<0.05）。在恶性病变检测方面，US的敏感性和特异性分别为100%（CI 95%；88 - 100）和90%（CI 95%；76 - 97）。通过ROC曲线分析获得应变比的最佳值（4.25）时，诊断恶性病变的敏感性和特异性分别为86%（CI 95%；70 - 95）和76%（CI 95%；60 - 87）。
RTE在乳腺良恶性肿块的鉴别中可发挥重要作用，但应与超声联合使用。
