Awal Guneet, Kaur Simplepreet
Drs. Awal and Kaur are with the Department of Dermatology, Venereology & Leprosy, Sri Guru Ram Das Institute of Medical Sciences and Research in Amritsar, India.
J Clin Aesthet Dermatol. 2018 Apr;11(4):25-27. Epub 2018 Apr 1.
Neurodegenerative disorders such as Alzheimer's disease and localized cutaneous macular amyloidosis are conditions that result from protein misfolding. These disorders share common pathogenic mechanisms that lead to the deposition of amyloid protein. Currently, there is a paucity of data on the connection between the brain and skin amyloidosis. Few recent studies have demonstrated a strong connection between the brain and skin in different amyloid diseases. Here, we report a case of concurrent occurrence of skin and brain amyloidoses and explore the brain-skin axis connection.
神经退行性疾病,如阿尔茨海默病和局限性皮肤黄斑淀粉样变,是由蛋白质错误折叠导致的病症。这些疾病具有共同的致病机制,会导致淀粉样蛋白沉积。目前,关于脑与皮肤淀粉样变之间的联系的数据很少。最近很少有研究表明在不同的淀粉样疾病中脑与皮肤之间存在紧密联系。在此,我们报告一例皮肤和脑淀粉样变同时发生的病例,并探讨脑-皮肤轴的联系。