Nilsson B, Carlström K, von Schoultz B
Department of Obstetrics and Gynecology, University Hospital, Umeå, Sweden.
J Steroid Biochem. 1988 Mar;29(3):293-5. doi: 10.1016/0022-4731(88)90029-5.
It is now well established that the activity of certain liver enzymes displays sex differences and that administration of human growth hormone to male rats alters the liver metabolism in a "female" direction. In this work we studied steroid sulfatase activity and binding of estradiol-17 beta in livers from intact rats and found a sex difference, with considerably higher enzyme activity in male as compared to female liver tissue. Continuous infusion of native and recombinant human growth hormone and estradiol-17 beta to male rats reduced sulfatase activity to "female" levels. A specific binding of estradiol-17 beta with receptor properties was found in the rat livers, but the concentration of binding sites did not change after administration of growth hormone or estradiol in this group of intact animals. Our data confirm previous reports that continuous administration of human growth hormone "feminize" liver metabolism, and since estradiol was found to have an identical effect on sulfatase activity it is suggested that the effect of estradiol-17 beta in this respect may be indirect, mediated via an altered secretory pattern of rat growth hormone.
现已充分证实，某些肝脏酶的活性存在性别差异，并且给雄性大鼠注射人生长激素会使肝脏代谢朝着“雌性”方向改变。在这项研究中，我们研究了完整大鼠肝脏中类固醇硫酸酯酶的活性以及雌二醇 - 17β 的结合情况，发现了性别差异，雄性肝脏组织中的酶活性明显高于雌性。向雄性大鼠持续输注天然和重组人生长激素以及雌二醇 - 17β 可使硫酸酯酶活性降至“雌性”水平。在大鼠肝脏中发现了具有受体特性的雌二醇 - 17β 的特异性结合，但在这组完整动物中，给予生长激素或雌二醇后，结合位点的浓度并未改变。我们的数据证实了先前的报道，即持续给予人生长激素会使肝脏代谢“雌性化”，并且由于发现雌二醇对硫酸酯酶活性具有相同的作用，因此表明雌二醇 - 17β 在这方面的作用可能是间接的，通过改变大鼠生长激素的分泌模式介导。
