Sharma Alok, Sane Hemangi, Gokulchandran Nandini, Badhe Prerna, Pai Suhasini, Kulkarni Pooja, Yadav Jayanti, Inamdar Sanket
Department of Medical Services and Clinical Research, NeuroGen Brain and Spine Institute, New Mumbai, Maharashtra, India.
Department of Research and Development, NeuroGen Brain and Spine Institute, New Mumbai, Maharashtra, India.
Adv Biomed Res. 2018 Mar 27;7:51. doi: 10.4103/2277-9175.228631. eCollection 2018.
Cellular therapy is being actively pursued as a therapeutic modality in many of the neurological diseases. A variety of stem cells from diverse sources have been studied in detail and have been shown to exhibit angiogenetic and immunomodulatory properties in addition to other neuroprotective effects. Published clinical data have shown bone marrow mononuclear cell (BMMNC) injection in neurological disorders is safe and possesses regenerative potential. We illustrate a case of 27-year-old male with traumatic brachial plexus injury, administered with autologous BMMNCs intrathecally and intramuscularly, followed by multidisciplinary rehabilitation. At the follow-up assessment of 3 and 7 months after first cell transplantation, improvements were recorded in muscle strength and movements. Electromyography (EMG) performed after the intervention showed a response in biceps and deltoid muscles suggesting the process of reinnervation at the site of injury. In view of the improvements observed after the treatment, the patient underwent second cell transplantation 8 months after the first transplantation. Muscle wasting had completely stopped with an increase in the muscle girth. No adverse effects were noted. Improvements were maintained for 4 years. A comprehensive randomized study for this type of injury is needed to establish the therapeutic benefits of cellular therapy.
细胞疗法正作为一种治疗方式在许多神经系统疾病中被积极探索。来自不同来源的多种干细胞已被详细研究，并且除了其他神经保护作用外，还显示出具有血管生成和免疫调节特性。已发表的临床数据表明，在神经系统疾病中注射骨髓单个核细胞（BMMNC）是安全的，并且具有再生潜力。我们举例介绍了一名27岁男性创伤性臂丛神经损伤患者，经鞘内和肌肉内注射自体BMMNC，随后进行多学科康复治疗。在首次细胞移植后3个月和7个月的随访评估中，记录到肌肉力量和运动能力有所改善。干预后进行的肌电图（EMG）显示肱二头肌和三角肌有反应，提示损伤部位有神经再支配过程。鉴于治疗后观察到的改善情况，患者在首次移植8个月后接受了第二次细胞移植。肌肉萎缩完全停止，肌肉周长增加。未观察到不良反应。改善情况持续了4年。需要针对此类损伤进行全面的随机研究，以确定细胞疗法的治疗益处。
