Revenko S V, Tikhomirova L N, Nesterov A V, Tarakanov I A
Department of Physiology, National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia.
Laboratory of General Pathology of the Cardiorespiratory System, Research Institute of General Pathology and Pathological Physiology, Russian Academy of Sciences, Moscow, Russia.
Bull Exp Biol Med. 2018 Apr;164(6):701-706. doi: 10.1007/s10517-018-4062-5. Epub 2018 Apr 16.
In experiments on narcotized rats, BP in the left femoral artery as well as local electrical potential and electrical impedance of the symmetric segment of the right femoral artery were simultaneously recorded in situ with two extracellular nonpolarizable Ag/AgCl electrodes located along the artery at a distance of 3 mm from each other. The pulsatile arterial electrical potentials with amplitude of 100-200 μV and duration of about 50 msec were recorded, which coincided with the front of BP wave corrected for a 10-msec delay of the pressure transducer. Under normal conditions, the pulsatile oscillations of arterial electroimpedance were in-phase with BP oscillations, so the rising phase of BP was paralleled by elevation of electroimpedance reflecting constriction of the arterial segment. This finding is viewed as indicative of periodic myogenic Ostroumov-Bayliss effect triggered by arterial pulse. After local application of tetrodotoxin (3×10 М), procaine (0.5%), or lidocaine (spray 10%) to isolated arterial segment, its electroimpedance oscillated out-of-phase with BP, so the changes of electroimpedance were similar to the response of a passive elastic tube to pulsatile BP. The applied agents completely (tetrodotoxin) or pronouncedly (procaine, lidocaine) inhibited the pulsatile arterial electrical potential. The present data indicate the possibility of passive and active modes of arterial pulsing, which differ by the amplitude of pulsatile arterial electrical potential as well as by phasic relations between BP and electroimpedance. The possible physiological role of various modes of pulsing in major arteries is discussed.
在对麻醉大鼠进行的实验中，使用两个彼此相距3毫米沿动脉放置的细胞外非极化银/氯化银电极，在原位同时记录左股动脉的血压以及右股动脉对称段的局部电位和电阻抗。记录到脉动动脉电位，其幅度为100 - 200μV，持续时间约为50毫秒，这与校正压力传感器10毫秒延迟后的血压波前沿一致。在正常情况下，动脉电阻抗的脉动振荡与血压振荡同相，因此血压上升阶段伴随着电阻抗升高，反映动脉段收缩。这一发现被视为动脉脉搏触发的周期性肌源性奥斯特鲁莫夫 - 贝利斯效应的指示。在对离体动脉段局部应用河豚毒素（3×10⁻³ М）、普鲁卡因（0.5%）或利多卡因（喷雾10%）后，其电阻抗与血压异相振荡，因此电阻抗变化类似于被动弹性管对脉动血压的反应。所应用的药物完全（河豚毒素）或显著（普鲁卡因、利多卡因）抑制了脉动动脉电位。目前的数据表明动脉搏动存在被动和主动模式的可能性，这两种模式在脉动动脉电位幅度以及血压与电阻抗的相位关系方面有所不同。讨论了大动脉中各种搏动模式可能的生理作用。
