Tikhomirova L N, Medvedeva Yu S, Lebedeva M A, Gavrilov I Yu, Revenko S V, Karganov M Yu, Popov E G, Tarakanov I A
Laboratory of General Pathology of Cardiorespiratory System, Research Institute of General Pathology and Pathophysiology, Moscow, Russia.
Department of Physico-Chemical and Environmental Pathophysiology, Research Institute of General Pathology and Pathophysiology, Moscow, Russia.
Bull Exp Biol Med. 2024 Nov;178(1):24-29. doi: 10.1007/s10517-024-06276-9. Epub 2024 Nov 22.
The rheographic parameters of the segments of brachial and femoral arteries were measured in situ after a 14-day-long hindlimb unloading (HU) of rats. HU significantly increased electrical impedance Z of a segment of femoral artery indicating its constriction; in parallel, HU resulted in a decreasing trend of Z of a segment of brachial artery attesting to its dilation. In both arteries, HU significantly or as a trend decreased the swing ranges of active and passive pulsations, respectively. BP reduction during bloodletting induced transition from passive to active pulsatile mode in the femoral artery only in 33% experimental rats in contrast to 87% control ones. We suppose that degradation of active pulsatile mode is responsible for the negative influences of microgravity and weightlessness on blood circulation. The study determined the rheographic parameters that reliably reflect changes in the functional activity of arteries after chronic redistribution of hydrostatic load.
在对大鼠进行为期14天的后肢卸载（HU）后，在原位测量肱动脉和股动脉各节段的血流图参数。HU显著增加了股动脉节段的电阻抗Z，表明其收缩；同时，HU导致肱动脉节段的Z呈下降趋势，证明其扩张。在两条动脉中，HU分别显著或呈趋势性降低了主动和被动搏动的摆动范围。放血期间血压降低仅在33%的实验大鼠中诱导股动脉从被动搏动模式转变为主动搏动模式，而对照组为87%。我们推测主动搏动模式的退化是微重力和失重对血液循环产生负面影响的原因。该研究确定了能够可靠反映慢性静水负荷重新分布后动脉功能活动变化的血流图参数。
