Montemurro Severino, Ammendola Michele, Gallo Gaetano, Romano Roberto, Condoluci Antonietta, Curto Lucia, De Franciscis Stefano, Serra Raffaele, Sacco Rosario, Sammarco Giuseppe
Unit of Surgery, Giovanni Paolo II Research Center, National Cancer Institute, Bari, Italy.
Unit of Surgery, Giovanni Paolo II Research Center, National Cancer Institute, Bari, Italy -
Minerva Chir. 2019 Feb;74(1):19-25. doi: 10.23736/S0026-4733.18.07755-6. Epub 2018 Apr 13.
Colorectal cancer is one of the most common invasive cancers, and it is responsible for considerable physical and psychosocial morbidity specially in older patients. However, only few reports focused on quality of life, cost-effectiveness and clinical outcomes of rectal cancer patients undergone to surgery. This retrospective study compares short-term and long-term outcomes in rectal cancer patients with more and less than 75 years of age.
Four hundred consecutive patients underwent radical surgery for rectal adenocarcinoma and they were collected in a prospective institutional database and divided into two groups: group 1 (≥75 years, N.=98); group 2 (<75 years, N.=302). Rectal anterior resection (RAR) with sphincter-saving restorative proctectomy and with application of silicone transanal tube NO COIL® 60-80 mm long, was the only procedure considered. Main clinical and pathological data were assessed and compared.
Statistically significant differences between the two groups were detected regard to comorbidities and the emergency presentation. Overall survival is lower in patients over 75 age, but cancer-related survival is not different between the two groups.
Although advanced age is associated with higher morbidity and mortality, in our experience, itself is not a contraindication for surgical sphincter-saving proctetomy in rectal cancer patients. The absence of a stoma also improved the cost effectiveness and patients' quality of life in both groups: psychological morbidity, sexuality, levels of anxiety and depression, body image.
结直肠癌是最常见的侵袭性癌症之一,尤其在老年患者中会导致相当严重的身心疾病。然而,仅有少数报告关注接受手术的直肠癌患者的生活质量、成本效益和临床结局。这项回顾性研究比较了年龄在75岁及以上和75岁以下的直肠癌患者的短期和长期结局。
连续400例接受直肠腺癌根治性手术的患者被纳入前瞻性机构数据库,并分为两组:第1组(≥75岁,n = 98);第2组(<75岁,n = 302)。仅考虑采用保留括约肌的直肠前切除术(RAR),即保留肛门的直肠切除术,并应用60 - 80毫米长的硅胶经肛引流管NO COIL®。评估并比较主要的临床和病理数据。
在合并症和急诊情况方面,两组之间存在统计学上的显著差异。75岁以上患者的总生存率较低,但两组之间的癌症相关生存率并无差异。
尽管高龄与较高的发病率和死亡率相关,但根据我们的经验,高龄本身并非直肠癌患者行保留括约肌直肠切除术的禁忌证。无造口也提高了两组的成本效益和患者生活质量:心理疾病、性功能、焦虑和抑郁水平、身体形象。