Larsson-Sciard E L, Coutinho A
Department of Immunology, University of Stockholm.
Ann Inst Pasteur Immunol. 1988 Jan-Feb;139(1):55-70. doi: 10.1016/0769-2625(88)90131-6.
We have recently described an autonomously activated set of T cells in the spleens of normal and "antigen-free" mice which display effector T helper (TH) or T suppressor (TS) activities; we describe here an intrathymic effector T-cell compartment which directly helps or suppresses B-cell responses and appears to be distinct from the peripheral set of effector cells. Splenic effector T cells do not represent recent thymic migrants (because adult thymectomized mice have unaltered levels of effector TH and TS cells in the spleen), nor do intrathymic effector T cells represent circulating peripheral T cells (since thymic effector T cells are B2A2+, while splenic effector T cells are B2A2-). Furthermore, effector TH cells within the two compartments exert differential effector activities: splenic effector TH cells induce B cells to both proliferation and maturation, while thymic effector TH cells are defective in activating B-cell maturation. The present findings extend our studies on "natural" lymphocyte activities in the normal immune system, revealing the existence of two apparently distinct effector T-cell compartments. The potential significance of the intrathymic set of effector cells in repertoire selection is considered.
我们最近描述了在正常和“无抗原”小鼠脾脏中一组自主激活的T细胞，它们表现出效应性辅助性T细胞（TH）或抑制性T细胞（TS）活性；我们在此描述了一个胸腺内效应性T细胞区室，它直接帮助或抑制B细胞反应，并且似乎与外周效应细胞群不同。脾效应性T细胞不代表近期来自胸腺的迁移细胞（因为成年去胸腺小鼠脾脏中效应性TH和TS细胞水平未改变），胸腺内效应性T细胞也不代表循环外周T细胞（因为胸腺效应性T细胞是B2A2 +，而脾效应性T细胞是B2A2 -）。此外，两个区室内的效应性TH细胞发挥不同的效应活性：脾效应性TH细胞诱导B细胞增殖和成熟，而胸腺效应性TH细胞在激活B细胞成熟方面存在缺陷。目前的研究结果扩展了我们对正常免疫系统中“天然”淋巴细胞活性的研究，揭示了两个明显不同的效应性T细胞区室的存在。我们还考虑了胸腺内效应细胞群在受体库选择中的潜在意义。
