Deray G, Maistre G, Cacoub P, Carayon A, Leger P, Rottembourg J, Anouar M, Sassano P, Cabrol C
Department of Nephrology, Hôpital Pitie-Salpetrière, Paris, France.
Eur J Clin Pharmacol. 1988;34(1):91-3. doi: 10.1007/BF01061425.
Plasma atrial natriuretic peptide (ANP) concentrations were measured by radioimmunoassay 1 to 12 days after operation in six patients with artificial hearts. The mean levels were significantly higher in artificial heart recipients (58.2 pg.ml-1) than in controls (12.6 pg.ml-1). The mechanism underlying the raised values is not clear, although it is suggested that elevated atrial pressure may have been the stimulus for higher ANP release. In 3 patients plasma ANP concentrations were also measured 1 to 5 days after orthotopic transplantation. In all of them ANP concentrations had increased by 20 to 74% despite lower right atrial pressure. An increase in atrial tissue mass may have contributed to the raised plasma ANP after orthotopic transplantation. It also suggests that the functioning sympathetic nervous system is not a necessary condition for ANP release.
对6例植入人工心脏的患者在术后1至12天通过放射免疫分析法测定血浆心钠素（ANP）浓度。人工心脏接受者的平均水平（58.2 pg/ml-1）显著高于对照组（12.6 pg/ml-1）。尽管有人认为心房压力升高可能是促使ANP释放增加的刺激因素，但ANP值升高的潜在机制尚不清楚。对3例原位心脏移植患者在术后1至5天也测定了血浆ANP浓度。尽管右心房压力降低，但所有患者的ANP浓度均升高了20%至74%。心房组织质量增加可能是原位心脏移植后血浆ANP升高的原因之一。这也表明，正常运作的交感神经系统并非ANP释放的必要条件。
