Molaie M, Cruz A, Culebras A
Department of Neurology, SUNY Health Science Center, Syracuse.
Neurology. 1988 May;38(5):759-62. doi: 10.1212/wnl.38.5.759.
We compared the nocturnal plasma prolactin (PRL) and beta-endorphin (B-E) concentrations prior to and after sleep deprivation (SD) in eight epileptic patients with complex partial seizures. After the period of SD (1) the mean number of interictal epileptiform discharges and the mean plasma PRL levels showed a significant rise during light non-REM stages of sleep, and (2) mean nocturnal plasma PRL and B-E concentrations showed a moderate rise during the first few hours of sleep, significant only for plasma PRL. In a patient with multiple complex partial seizures during sleep, the levels of plasma PRL and B-E concentrations were closely related to ictal discharges. The data obtained in this stress-free environment suggest a centrally mediated interaction between the release of PRL and B-E, in relation to epileptic discharges.
我们比较了8例复杂部分性发作癫痫患者在睡眠剥夺（SD）前后的夜间血浆催乳素（PRL）和β-内啡肽（B-E）浓度。在睡眠剥夺期后：（1）平均发作间期癫痫样放电次数和平均血浆PRL水平在浅睡眠非快速眼动期显著升高；（2）平均夜间血浆PRL和B-E浓度在睡眠最初几个小时有适度升高，仅血浆PRL升高显著。在一名睡眠期间有多次复杂部分性发作的患者中，血浆PRL和B-E浓度水平与发作期放电密切相关。在这个无应激环境中获得的数据表明，PRL和B-E的释放之间存在中枢介导的相互作用，与癫痫放电有关。
