Molaie M, Culebras A, Miller M
Ann Neurol. 1985 Dec;18(6):719-22. doi: 10.1002/ana.410180616.
We measured plasma prolactin and cortisol concentrations in 12 epileptic men with complex partial seizures during all-night polygraphic recording, with continuous video monitoring and sequential blood sampling at 30-minute intervals. There was a significant but moderate elevation of all-night mean plasma prolactin concentration (p less than 0.001), but not of cortisol, in epileptics when compared with normal subjects studied in a similar fashion. The data obtained in this environmentally controlled study of males with complex partial seizure disorder indicate a disruption of prolactin regulatory mechanisms resulting in a modest elevation of plasma concentrations independent of ictal electrographic discharges.
我们在12名患有复杂部分性发作的癫痫男性患者进行通宵多导睡眠图记录期间，通过连续视频监测以及每隔30分钟进行一次序贯采血，测量了血浆催乳素和皮质醇浓度。与以类似方式研究的正常受试者相比，癫痫患者的通宵平均血浆催乳素浓度有显著但中等程度的升高（p小于0.001），而皮质醇浓度没有升高。在这项对患有复杂部分性癫痫障碍男性进行的环境控制研究中获得的数据表明，催乳素调节机制受到破坏，导致血浆浓度适度升高，且与发作期脑电图放电无关。
