Molaie M, Culebras A, Miller M
Arch Neurol. 1987 Jul;44(7):699-702. doi: 10.1001/archneur.1987.00520190011008.
The nocturnal pattern of plasma prolactin (PRL) and cortisol in male epileptics with complex partial seizures and primary generalized seizures was studied by all-night polygraphic recordings with continuous video monitoring and sequential blood sampling at 30-minute intervals. Mean nocturnal plasma PRL concentrations in both groups of epileptics were significantly elevated when compared with nonepileptic control subjects studied in a similar fashion. Eight subclinical and three clinical partial seizures were recorded during sleep. Although a tenfold increase of plasma PRL level occurred following a short brief clinical complex partial seizure, there was no direct correlation between single subclinical partial seizures and nocturnal fluctuations of plasma PRL concentrations. We did not observe recognizable plasma cortisol changes following partial seizures during sleep, nor significant differences of mean nocturnal plasma cortisol levels between epileptics and controls. The data obtained in this environmentally controlled study indicate that postictal elevation of plasma PRL is a specific phenomenon related to seizure discharges; however, failure of such a rise does not exclude partial seizures.
通过整夜多导睡眠图记录、连续视频监测以及每隔30分钟进行一次序贯采血，对患有复杂部分性发作和原发性全身性发作的男性癫痫患者血浆催乳素（PRL）和皮质醇的夜间模式进行了研究。与以类似方式研究的非癫痫对照受试者相比，两组癫痫患者的夜间血浆PRL平均浓度均显著升高。睡眠期间记录到8次亚临床发作和3次临床部分性发作。尽管一次短暂的临床复杂部分性发作后血浆PRL水平增加了10倍，但单次亚临床部分性发作与血浆PRL浓度的夜间波动之间没有直接相关性。我们没有观察到睡眠期间部分性发作后血浆皮质醇有可识别的变化，癫痫患者与对照组之间夜间血浆皮质醇平均水平也没有显著差异。在这项环境受控研究中获得的数据表明，发作后血浆PRL升高是与癫痫放电相关的一种特定现象；然而，这种升高未出现并不排除部分性发作。
