Talpur H S, Chandio I B, Brohi R D, Worku T, Rehman Z, Bhattarai D, Ullah F, JiaJia L, Yang L
Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Education Ministry of China, Huazhong Agricultural University, Wuhan, China.
Shaheed Benazir Bhutto University of Veterinary and Animal Sciences, Sakrand, Pakistan.
Reprod Domest Anim. 2018 Aug;53(4):831-849. doi: 10.1111/rda.13188. Epub 2018 Apr 16.
Melatonin and its receptors play a crucial role in the regulation of the animal reproductive process, primarily in follicular development. However, the role that melatonin performs in regulating hormones related with reproduction remains unclear. Melatonin and its receptors are present both in female and male animals' organs, such as ovaries, heart, brain and liver. Melatonin regulates ovarian actions and is a key mediator of reproductive actions. Melatonin has numerous effects on animal reproduction, such as protection of gametes and embryos, response to clock genes, immune-neuroendocrine, reconciliation of seasonal variations in immune function, and silence or blockage of genes. The growth ratio of reproductive illnesses in animals has raised a remarkable concern for the government, animal caretakers and farm managers. In order to resolve this challenging issue, it is very necessary to conduct state-of-the-art research on melatonin and its receptors because melatonin has considerable physiognomies. This review article presents a current contemporary research conducted by numerous researchers from the entire world on the role of melatonin and its receptors in animal reproduction, from the year 1985 to the year 2017. Furthermore, this review shows scientific research challenges related to melatonin receptors and their explanations based on the findings of 172 numerous research articles, and also represents significant proficiencies of melatonin in order to show enthusiastic study direction for animal reproduction researchers.
褪黑素及其受体在动物生殖过程的调节中起着至关重要的作用，主要是在卵泡发育方面。然而，褪黑素在调节与生殖相关激素方面所起的作用仍不清楚。褪黑素及其受体存在于雌性和雄性动物的器官中，如卵巢、心脏、大脑和肝脏。褪黑素调节卵巢功能，是生殖功能的关键调节因子。褪黑素对动物生殖有多种影响，如保护配子和胚胎、对生物钟基因的反应、免疫-神经内分泌、调节免疫功能的季节性变化以及基因的沉默或阻断。动物生殖疾病的增长率引起了政府、动物饲养者和农场管理者的极大关注。为了解决这个具有挑战性的问题，对褪黑素及其受体进行前沿研究非常必要，因为褪黑素具有相当多的特性。这篇综述文章展示了1985年至2017年期间世界各地众多研究人员对褪黑素及其受体在动物生殖中的作用所进行的当代研究。此外，本综述基于172篇众多研究文章的发现，展示了与褪黑素受体相关的科学研究挑战及其解释，还阐述了褪黑素的重要特性，以便为动物生殖研究人员指明积极的研究方向。
