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褪黑素:人类生殖中的“希格斯玻色子”。

Melatonin: a "Higgs boson" in human reproduction.

作者信息

Dragojevic Dikic Svetlana, Jovanovic Ana Mitrovic, Dikic Srdjan, Jovanovic Tomislav, Jurisic Aleksandar, Dobrosavljevic Aleksandar

机构信息

Department of Obstetrics and Gynecology "Narodni front" .

出版信息

Gynecol Endocrinol. 2015 Feb;31(2):92-101. doi: 10.3109/09513590.2014.978851. Epub 2014 Nov 7.

DOI:10.3109/09513590.2014.978851
PMID:25377724
Abstract

As the Higgs boson could be a key to unlocking mysteries regarding our Universe, melatonin, a somewhat mysterious substance secreted by the pineal gland primarily at night, might be a crucial factor in regulating numerous processes in human reproduction. Melatonin is a powerful antioxidant which has an essential role in controlling several physiological reactions, as well as biological rhythms throughout human reproductive life. Melatonin, which is referred to as a hormone, but also as an autocoid, a chronobiotic, a hypnotic, an immunomodulator and a biological modifier, plays a crucial part in establishing homeostatic, neurohumoral balance and circadian rhythm in the body through synergic actions with other hormones and neuropeptides. This paper aims to analyze the effects of melatonin on the reproductive function, as well as to shed light on immunological and oncostatic properties of one of the most powerful hormones.

摘要

由于希格斯玻色子可能是解开有关我们宇宙奥秘的关键,褪黑素这种主要在夜间由松果体分泌的 somewhat mysterious substance,可能是调节人类生殖中众多过程的关键因素。褪黑素是一种强大的抗氧化剂,在控制多种生理反应以及贯穿人类生殖生活的生物节律方面具有重要作用。褪黑素既被称为一种激素,也被称作自分泌调节物质、时间生物学剂、催眠剂、免疫调节剂和生物调节剂,它通过与其他激素和神经肽的协同作用,在建立体内的稳态、神经体液平衡和昼夜节律方面发挥着关键作用。本文旨在分析褪黑素对生殖功能的影响,并阐明这种最强大的激素之一的免疫和抑癌特性。

相似文献

1
Melatonin: a "Higgs boson" in human reproduction.褪黑素:人类生殖中的“希格斯玻色子”。
Gynecol Endocrinol. 2015 Feb;31(2):92-101. doi: 10.3109/09513590.2014.978851. Epub 2014 Nov 7.
2
Melatonin and human reproduction: shedding light on the darkness hormone.褪黑素与人类生殖:揭开黑暗激素的神秘面纱。
Gynecol Endocrinol. 2009 Dec;25(12):779-85. doi: 10.3109/09513590903159649.
3
Human pineal physiology and functional significance of melatonin.人类松果体生理学及褪黑素的功能意义。
Front Neuroendocrinol. 2004 Sep-Dec;25(3-4):177-95. doi: 10.1016/j.yfrne.2004.08.001.
4
[Pineal hormone melatonin is an universal adaptogenic agent].松果体激素褪黑素是一种普遍的适应原性物质。
Usp Fiziol Nauk. 2012 Jul-Sep;43(3):82-100.
5
[Melatonin in the human--an overview].[褪黑素与人类——综述]
Wien Klin Wochenschr. 1997 Oct 3;109(18):707-13.
6
Melatonin and female reproduction.褪黑素与女性生殖
J Obstet Gynaecol Res. 2014 Jan;40(1):1-11. doi: 10.1111/jog.12177. Epub 2013 Oct 7.
7
60 YEARS OF NEUROENDOCRINOLOGY: Regulation of mammalian neuroendocrine physiology and rhythms by melatonin.神经内分泌学60年:褪黑素对哺乳动物神经内分泌生理和节律的调节
J Endocrinol. 2015 Aug;226(2):T187-98. doi: 10.1530/JOE-15-0119. Epub 2015 Jun 22.
8
Melatonin and the pineal gland: influence on mammalian seasonal and circadian physiology.褪黑素与松果体:对哺乳动物季节性和昼夜生理的影响。
Rev Reprod. 1998 Jan;3(1):13-22. doi: 10.1530/ror.0.0030013.
9
[Present and future of melatonin in human and animal reproduction functions].[褪黑素在人类和动物生殖功能中的现状与未来]
Contracept Fertil Sex. 1993 Oct;21(10):727-32.
10
[Melatonin effects on the female genital system: a brief review].
Rev Assoc Med Bras (1992). 2008 May-Jun;54(3):267-71. doi: 10.1590/s0104-42302008000300022.

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Melatonin: a modulator in metabolic rewiring in T-cell malignancies.褪黑素:T细胞恶性肿瘤代谢重塑的调节因子。
Front Oncol. 2024 Jan 8;13:1248339. doi: 10.3389/fonc.2023.1248339. eCollection 2023.
2
Central precocious puberty secondary to peripheral precocious puberty due to a pineal germ cell tumor: a case and review of literature.松果体生殖细胞瘤导致外周性性早熟继发中枢性性早熟 1 例报告并文献复习
BMC Endocr Disord. 2023 Oct 26;23(1):237. doi: 10.1186/s12902-023-01494-0.
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The Role of Promyelocytic Leukemia Zinc Finger (PLZF) and Glial-Derived Neurotrophic Factor Family Receptor Alpha 1 (GFRα1) in the Cryopreservation of Spermatogonia Stem Cells.
原始生殖细胞冷冻保存中早幼粒细胞白血病锌指蛋白(PLZF)和胶质细胞源性神经营养因子家族受体 α1(GFRα1)的作用。
Int J Mol Sci. 2023 Jan 18;24(3):1945. doi: 10.3390/ijms24031945.
4
Effects of seasonal variations and meteorological factors on IVF pregnancy outcomes: a cohort study from Henan Province, China.季节变化和气象因素对体外受精妊娠结局的影响:来自中国河南省的一项队列研究。
Reprod Biol Endocrinol. 2022 Aug 6;20(1):113. doi: 10.1186/s12958-022-00986-3.
5
Melatonin in cryopreservation media improves transplantation efficiency of frozen-thawed spermatogonial stem cells into testes of azoospermic mice.在冷冻保存介质中添加褪黑素可提高冷冻-解冻精原干细胞移植到无精子症小鼠睾丸中的移植效率。
Stem Cell Res Ther. 2022 Jul 26;13(1):346. doi: 10.1186/s13287-022-03029-1.
6
Melatonin Signaling Pathways Implicated in Metabolic Processes in Human Granulosa Cells (KGN).褪黑素信号通路在人颗粒细胞(KGN)代谢过程中的作用
Int J Mol Sci. 2022 Mar 10;23(6):2988. doi: 10.3390/ijms23062988.
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Melatonin promotes the development of sheep transgenic cloned embryos by protecting donor and recipient cells.褪黑素通过保护供体细胞和受体细胞来促进绵羊转基因克隆胚胎的发育。
Cell Cycle. 2022 Jul;21(13):1360-1375. doi: 10.1080/15384101.2022.2051122. Epub 2022 Mar 20.
8
Research progress of melatonin (MT) in improving ovarian function: a review of the current status.褪黑素(MT)改善卵巢功能的研究进展:现状综述。
Aging (Albany NY). 2021 Jul 6;13(13):17930-17947. doi: 10.18632/aging.203231.
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Melatonin and neuroblastoma: a novel therapeutic approach.褪黑素与神经母细胞瘤:一种新型治疗方法。
Mol Biol Rep. 2021 May;48(5):4659-4665. doi: 10.1007/s11033-021-06439-1. Epub 2021 Jun 1.
10
Melatonin induces progesterone production in human granulosa-lutein cells through upregulation of StAR expression.褪黑素通过上调类固醇生成急性调节蛋白(StAR)的表达诱导人颗粒黄体细胞产生孕酮。
Aging (Albany NY). 2019 Oct 16;11(20):9013-9024. doi: 10.18632/aging.102367.