Lou Yunpeng, Lin Zhaofen
Department of Emergency and Critical Care, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China (Lou YP, Lin ZF); Department of Intensive Care Unit, No.401 Hospital of Chinese People's Liberation Army, Qingdao 266071, Shandong, China (Lou YP). Corresponding author: Lin Zhaofen, Email:
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2018 Apr;30(4):374-376. doi: 10.3760/cma.j.issn.2095-4352.2018.04.018.
Sepsis is a common disease in intensive care units (ICU), and the resulted multi-organ dysfunction syndrome (MODS) is the main cause of death in patients with severe sepsis. The cardiovascular system is one of the most important target organ for sepsis. The severity of cardiac dysfunction is closely related to the clinical prognosis of patients with sepsis. Studies have reported that various cytokines are expressed during sepsis. They have influence on myocardial contractile function, mitochondrial function and self-regulation. Where after, it will induce cardiomyocyte apoptosis, which can lead to myocardial dysfunction. In this article, the pathogenesis of sepsis-induced myocardial dysfunction (SIMD) were reviewed to further clarify the pathogenesis of SIMD, and provide theoretical basis for subsequent research.
脓毒症是重症监护病房（ICU）中的常见疾病，由此导致的多器官功能障碍综合征（MODS）是严重脓毒症患者死亡的主要原因。心血管系统是脓毒症最重要的靶器官之一。心脏功能障碍的严重程度与脓毒症患者的临床预后密切相关。研究报道，脓毒症期间多种细胞因子表达。它们对心肌收缩功能、线粒体功能及自我调节产生影响。此后，会诱导心肌细胞凋亡，进而导致心肌功能障碍。本文对脓毒症诱导的心肌功能障碍（SIMD）的发病机制进行综述，以进一步阐明SIMD的发病机制，并为后续研究提供理论依据。
